三种非甾体抗炎药物在患儿中的退热疗效研究  

Study the pyretolysis effect of three NSAIDs in pedia-patients

作　　者：王健康[1] 董晓莉[1] 郑春茜[2] 纪蕾[1] 

机构地区：[1]空军总医院药学部,北京100142 [2]空军总医院儿科,北京100142

出　　处：《空军总医院学报》2010年第4期196-198,共3页Journal of General Hospital of Air Force,PLA

摘　　要：目的评价三种非甾体抗炎药物(NSAIDs)对于患儿的药效学特点,为临床护理及合理用药提供依据。方法采用回顾性研究方法对144名确诊为感染性发热的患儿进行分析,入组的数据按年龄因素和药物因素分组,析因分析采用两因素方差分析法,组间数据两两比较采用SNK分析法,评价患儿退热效果和影响退热效果的因素。结果资料显示,影响药效学的因素不是年龄因素而是药物因素。三种药物在药效上存在差异,其吲哚美辛栓降温效果和药效持续时间最强。结论应根据药物的药效特点合理使用退热药物。Objective The therapeutic effect of three NSAIDs in pedia-patients was evaluated,in order to provide evidence for clinical nursing care and rational administration.Methods A retrospective method was performed,144 pedia-patients who were final diagnosis infectivity fever were adopted and were grouped accordance with factors age and drugs.Factor analysis was adopted with two way analysis of variance method,group data were compared each other with Student-Newman-Keuls Method.Results The basic information of subjects showed that the each groups can be compared.It is the drug but the age is the exact factor which affected the pharmacodynamics and Indometacin suppositories has the most hypothermy effect and lasting time.Conclusion It should administrat drugs with it′s pharmacodynamics character.

关 键 词：阿斯匹林/药理学 布洛芬/药理学 吲哚美辛/药理学 儿童 发热/治疗 

分 类 号：R96[医药卫生—药理学]