广西壮族与汉族白细胞介素-6基因启动子MbiⅠ多态性的分布特点  

Distribution of interleukin-6 gene promoter region Mbi I polymorphism in Zhuang and Han nationality in Guangxi province

作　　者：韦叶生[1] 蓝艳[2] 徐群清[1] 李壮[1] 

机构地区：[1]右江民族医学院附属医院临床检验中心,百色533000 [2]右江民族医学院附属医院皮肤科,百色533000

出　　处：《解剖学杂志》2005年第4期381-382,442,共3页Chinese Journal of Anatomy

基　　金：广西壮族自治区卫生厅课题(Z2004036)广西壮族自治区教育厅课题(200420)

摘　　要：目的:了解白细胞介素-6基因启动子MbiⅠ多态性在中国广西不同民族中的分布。方法:应用聚合酶链反应-限制性片段长度多态性技术检测壮族和汉族人的白细胞介素-6基因启动子Mbi Ⅰ多态性,比较2组白细胞介素-6基因型和等位基因的分布频率。结果:在壮族人中CC基因型占56.22%、CG基因型占41.08%、GG基因型占2.70%;在汉族人中CC基因型占66.67%、CG基因型占32.32%、GG基因型占1.01%。两组白细胞介素-6基因型的分布频率差异有显著性。结论:壮族与汉族白细胞介素-6基因Mbi Ⅰ多态性分布频率差异有显著性。To detect the distribution of interleukin-6 gene promoter region MbiⅠpolymorphism in the Chinese Zhuang and Han nationality in Guangxi province. Methods： Interleukin-6 gene promoter region Mbi Ⅰpolymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in Zhuang （n= 185） and Han （n= 198）. Results： The frequencies of CC, CG and GG genotypes were 56.22%, 41.08% and 2.70% in the Zhuangs, and 66.67%, 32.32% and 1.01% in the Han, respectively. A significant difference was seen in the distribution frequency of interleukin-6 genotype between the Zhuang and the Han （P〈0.05）. Conclusion： There is significant difference of interleukin-6 gene promoter region MbiⅠ polymorphism between the Zhuang and the Han.

关 键 词：广西 壮族 汉族 白细胞介素-6 基因启动子 MbiⅠ 基因多态性 基因频率 

分 类 号：R392[医药卫生—免疫学]