强啡肽和苯环利定在高血压大鼠的环腺苷酸生成系统中的作用  

EFFECTS OF DYNORPHINE AND PHENCYCLIDINE ON THE CYCLIC ADENOSINE MONOPHOS PHATE GENERATING SYSTEM IN THE SPONTANEOUSLY HYPERTENSIVE RATS PERIPHERAL ARTERIES

作　　者：包维丽[1] 张玲妹[1] 童杰飞 孙凤艳[1] 张安中[1] 

机构地区：[1]上海医科大学医学神经生物学国家重点实验室

出　　处：《神经科学》1995年第1期14-17,共4页Chinese Journal of Neuroscience

摘　　要：采用放射免疫检测方法，观察了强啡肽（Ｄｙｎ）和苯环利定（ＰＣＰ）对高血压大鼠（ＳＨＲ）的环腺苷酸（ｃＡＭＰ）生成系统的影响．结果表明：Ｄｙｎ剂量依赖地降低ＳＨＲ和非高血压大鼠（ＷＫｙ）的外周血管中ｃＡＭＰ的含量，并且对ＳＨＲ的ｃＡＭＰ生成系统的抑制作用大于ＷＫｙ（Ｐ＜０．０５）；相反地，ＰＣＰ剂量依赖地升高ＳＮＲ和ＷＫｙ的外周血管中的ｃＡＭＰ的含量，对ＳＨＲ的ｃＡＭＰ生成系统的激活作用小于ＷＫｙ（Ｐ＜０．０５）。这些观察表明：１．Ｄｙｎ和ＰＣＰ通过抑制或激活环腺苷酸生成系统对ＳＨＲ产生作用。２．ＳＨＲ和ＷＫｙ的外周动脉对Ｄｙｎ和ＰＣＰ的敏感性不同。Ｐ＜０．０１ｖｓＷＫｙ．ＥｆｆａｔＯｆ￣ｏｎｃＡＭＰｃｏｎａｌｓｏｆ￣ｎｅＰ￣Ｏｆ￣￣ｉｎＳＨＲａｎｄＷＫｙＩｎ￣ｎｇｃｏｎｒｍｈａｔｉｏｎｏｆＰＣＰ（１０－－＇－－１０－－＇ｍｏｌ／Ｌ）ｉｎｄｕｃｅａｄｏＳｅｄｒｐｅｎｄｅｎｔｉｎＣｒｅａｓｅｉｎｃＡＭＰｌｅＶｅｌｓｉｎｍｅｍｂｒａｎｅｐａ￣ｏｆｂｏｔｈＳＨＲａｎｄＷＫｙ．ＴｈｅＥＣ．ｖａｌｕｅＳｗｅｒｅ９．３ｘ１０－－７ｍｏｌ／ＬｆｏｒＷＫｙａｎｄ５．０ｘ１０－－６ｍｏｌ／ＬｆｏｒＳＨＲ．The effect of the kappa-receptor agonist dynorphine (Dyn) and the phencyclidine (PCP) -receptor agonist PCP on 3' -5' -cyclic adenosine monophosphate (cAMP)generating system of the spontaneously hypertensive rat (SHR) arteries was studied in vitro. Dyn decreased cAMP levels in a dose-dependent manner in both SHR and normotensive Wistar Kyoto rat (WKy) peripheral arteries, but the inhibitory effect of Dyn was statistically greater in the SHR arteries than that in the WKy ones. PCP increased cAMP levels in a dose-dependent manner in both SHR and WKy peripheral arteries. The stimulatory effect of PCP was statistically greater in the WKy arteries than that in the SHR ones. The findings indicate that (1) Dyn and PCP can affect SHR and WKy arteries through inhibition or activation of the adenylate-cyclase cAMP system, (2) the sensitivity of SHR arteries to Dyn and PCP was different from that of WKy arteries.

关 键 词：环单磷酸腺苷 苯环利定 强啡肽 高血压 

分 类 号：R544.102[医药卫生—心血管疾病]