阿片肽促进大鼠大脑皮层神经细胞谷氨酸释放、摄取及细胞内游离钙浓度增加  

OPIATES ENHANCED RELEASE AND UPTAKE OF GLUTAMATE AND INCREASED FREE INTRACELLULAR CALCIUM IN RAT CORTICOCE REBRAL NEURONS

作　　者：王朝晖[1] 粱英武 单巍松[1] 周江堡 吴希如[1] 

机构地区：[1]北京医科大学第一临床医学院儿科神经组

出　　处：《神经科学》1995年第4期164-167,共4页Chinese Journal of Neuroscience

基　　金：国家自然科学基金

摘　　要：本文以大鼠大脑皮层神经细胞为研究对象，探讨阿片肽β─内啡肽和亮脑啡肽对神经细胞的作用及其与谷氨酸释放、摄取和细胞内游离钙浓度的变化关系。结果表明：β─内啡肽及亮脑啡肽能促进大鼠大脑皮层神经细胞谷氨酸的释放、摄取和细胞内游离钙浓度增加。提示外源性阿片肽对神经细胞具有兴奋性作用，在惊厥性疾病的发生、发展过程中可能起着一定的作用。We studied the effect of β─endorphin and Leu─enkephalin (LE) on the newborn or cultured rat corticocerebral neurons and their relation to the release and uptake of glutamate in neurons and the level of free intracellular calcium. These results showed that β─endorphin and LE significantly enhanced release and uptake of glutamate in corticocerebral neurons and the increase in free intracellular calcium.These findings suggest that β─endorphin and LE play an important role in the pathogenesis of seizures.

关 键 词：阿片肽 神经兴奋性 神经细胞 

分 类 号：R338.2[医药卫生—人体生理学]