联合雾化吸入治疗急性发作期支气管哮喘患者的效果评价  

Evaluation on effectiveness of combination of aerosol inhalation in asthmatic patients with acute attack

作　　者：李晓丹[1] 许力军[1] 刘超英[1] 邹奇[1] 丛中凰[1] 王满[1] 张洪泉[1] 

机构地区：[1]吉林大学第一医院呼吸科,吉林长春130021

出　　处：《吉林大学学报（医学版）》2011年第6期1120-1123,共4页Journal of Jilin University：Medicine Edition

基　　金：国家高技术研究发展计划(863计划)项目资助课题(2006AA02Z491)

摘　　要：目的:探讨联合雾化吸入硫酸特布他林和布地奈德对急性发作期支气管哮喘患者β2-肾上腺素能受体(β2-ADR)、T淋巴细胞亚群、嗜酸性粒细胞(EOS)的影响及对肺功能的改善作用。方法:选取中、重度支气管哮喘急性发作患者56例,随机分为对照组和治疗组各28例。对照组患者采用多索茶碱加常规治疗;治疗组患者给予多索茶碱等常规治疗联合布地奈德和硫酸特布他林每日2次雾化吸入。疗程均2周。测定治疗前后患者外周血中β2-ADR、T淋巴细胞亚群水平及EOS计数、肺功能各项指标,对比两组患者治疗前后各项指标改善情况。结果:治疗后两组患者外周血β2-ADR水平均无明显变化(P>0.05);与治疗前比较,两组患者治疗后CD4、CD4/CD8及EOS绝对计数明显减低(P<0.05),最高呼气流速(PEF)及1秒率(FEV1/FVC)明显增高(P<0.05),治疗组比对照组改善更为明显(P<0.05)。结论:联合雾化吸入可改善哮喘患者哮喘发作状态,同时还能达到临床控制哮喘的目的。Objective To investigate the influence of terbutaline in combination with inhalation of budesonide on the β2-adrenergic receptor,T lymphocyte subgroup and eosinophile granulocyte(EOS) and the improvement effect on lung function in the acute attack asthmatic patients.Methods 56 patients with moderate and severe acute attack asthma were selected and randomly divided into control group and treatment group(n=28).The patients in control group were treated with common method such as doxofylline and the patients in treatment group were treated with an additional treatment by applying combination inhalation: budesonide + terbutaline,two times a day;the β2ADR,T lymphocyte subgroup,EOS,and lung function were detected before and after treatment.Results There was no change in the level of β2AR in peripheral blood of patients after treatment in two groups(P>0.05);CD4%,CD4/CD8 and EOS counts of the patients were obviously reduced(P<0.05),PEF and FEV1/FVC were obviously increased(P<0.05) after treatment in two groups,the effect was obvious in treatment group compared with control group(P<0.05).Conclusion The combination inhalation has the effect of improving asthmatic patient in acute attack period and achieving clinical control in the long term.

关 键 词：支气管哮喘 布地奈德 特布他林 Β2肾上腺素能受体 T细胞亚群 

分 类 号：R56[医药卫生—呼吸系统]