三苦滴丸成型工艺条件优选  

Optimization of preparation process for Sanku dropping pills

作　　者：董金香[1] 张馨月[1] 李兴杰[1] 邱智东[1] 

机构地区：[1]长春中医药大学药学院中药药剂教研室,吉林长春130117

出　　处：《吉林大学学报（医学版）》2011年第6期1149-1152,共4页Journal of Jilin University：Medicine Edition

基　　金：国家科技部科技重大专项基金资助课题(2009ZX09102-115)

摘　　要：目的:探讨三苦滴丸成型工艺的条件,为近一步开发治疗冠心病和心绞痛的中药新药提供依据。方法:以滴丸的溶散时限、丸重差异及外观(圆整度、硬度、色泽均匀性)作为评价指标,采用单因素考察法对三苦滴丸的冷却剂种类、滴距进行选择,采用正交实验法对2种基质的比例、药物与基质的比例及滴制时药液温度进行优选。结果:三苦滴丸最佳成型工艺条件是以二甲基硅油为冷却剂,PEG4000∶PEG6000=1∶6作为基质,药物与基质的比例为1∶2,药液温度80℃,滴距为5cm,滴速18～20滴.min-1。结论:优选出的成型工艺条件稳定可行,适合于大规模生产。Objective To explore the conditions of preparation technology of Sanku dropping pills and provide the basis for further development of traditional Chinese medicine in treatment of coronary heart disease and angina pectoris.Methods Time limit of dissolution,weight variation and appearance(length pellets,hardness,color uniformity) were used as evaluation indexes of the test,the single factor investigation method was adopt to select the variety of the matrix and the dropping distance;on the basis of orthogonal test,the good dropping conditions about the proportion of two types of matrix,matrix with the medicine and the temperature of liquid medicine were selected.Results The best pill formatting process was that the dimethyl silicon oil was used as refrigerant,the ratio of PEG 4000 to PEG6000 was 1∶6,the ratio of medicine to matrix was 1∶2,the dripping temperature was 80℃,the dropping distance was 5 cm,the dropping speed was 18-20 drops·min-1.Conclusion The optimized moulding process results is stable and feasible,suitable for mass production.

关 键 词：三苦滴丸 正交实验 成型工艺 

分 类 号：TQ46[化学工程—制药化工]