苦参碱对不完全脑缺血再灌注损伤小鼠的保护作用研究  

Matrine Alleviated Incomplete Cerebral Ischemia-Reperfusion Injury in Mice

作　　者：孟凡瑞[1] 王月娇[2] 孔玉梅[1] 王丹[1] 陈沉[1] 

机构地区：[1]辽宁大学药学院,辽宁沈阳110036 [2]中国医科大学,93期七年制辽宁沈阳110001

出　　处：《辽宁大学学报（自然科学版）》2011年第4期350-352,共3页Journal of Liaoning University：Natural Sciences Edition

基　　金：辽宁大学校内基金资助(2009LDQN32)

摘　　要：研究苦参碱对小鼠不完全脑缺血再灌注损伤的保护作用.实验采用结扎小鼠双侧颈总动脉30min,然后再灌注24 h,制备小鼠不完全脑缺血再灌注损伤模型.对不完全脑缺血再灌注小鼠,尾静脉给予不同剂量苦参碱治疗.不完全脑缺血再灌注小鼠脑水肿比对照组明显增加,脑组织MDA水平也明显增高,给予苦参碱治疗的小鼠脑水肿和脑组织MDA水平明显降低.因此,苦参碱能减轻不完全脑缺血再灌注小鼠的损伤.To investigate the effects of matrine on cerebral ischemia-reperfusion injury in mice,we applied incomplete cerebral ischemia-reperfusion model.In the model,bilateral carotid artery was occluded for 30min,and then reperfused for 24h.At the beginning of reperfusion,the mice were given intravenously matrine.In the study,brain edema of incomplete cerebral ischemia-reperfusion mice significantly increased compared with the control group,and brain tissue MDA levels were also significantly increased.Brain edema and brain tissue MDA levels in matrine treatment mice significantly decreased.Therefore,matrine can reduce the incomplete cerebral ischemia-reperfusion injury in mice.

关 键 词：苦参碱 不完全脑缺血再灌注 小鼠 

分 类 号：R28[医药卫生—中药学]