降糖药物对新发2型糖尿病患者肱动脉内皮功能的影响  

Effects in endothelial function of brachial artery in new patients with type 2 diabetes caused by medicines for reducing blood sugar

作　　者：邹春鹏[1] 孙海燕[1] 罗洪霞[1] 赵雅萍[1] 金慧佩[1] 吴笑英[2] 吴朝明[2] 

机构地区：[1]温州医学院附属第二医院超声科,浙江温州325027 [2]温州医学院附属第二医院内分泌科,浙江温州325027

出　　处：《医学影像学杂志》2012年第2期233-236,共4页Journal of Medical Imaging

基　　金：浙江省温州市科技局计划项目(Y20090304)

摘　　要：目的:探讨降糖药物对新发2型糖尿病患者肱动脉内皮功能的影响。方法:随机选取新发2型糖尿病患者87例,分为对照组46例和病例组41例。全部进行应变和应变率成像及冷加压试验,获得冷加压试验前后肱动脉的最大圆周应变和应变率,计算圆周应变和应变率储备。所有患者服用降糖药物6个月后再次计算圆周应变和应变率储备,并进行组间和组内对比分析。结果:对照组肱动脉圆周应变和应变率储备治疗后高于治疗前(P<0.05)。病例组肱动脉圆周应变和应变率储备治疗前后比较差异无统计学意义(P>0.05)。病例组肱动脉圆周应变和应变率储备在治疗前和治疗后均低于对照组(P<0.05)。结论:降糖药物对不合并血管并发症的新发2型糖尿病患者肱动脉内皮功能有较好的保护作用。Objective:To investigate the effects in endothelial function of brachial artery in new patients with type 2 diabetes caused by medicines for reducing blood sugar.Methods:Eighty-seven patients with type 2 diabetes were involved.The patients were divided into control group(46 cases) and case group(41 cases) according to the vascular complications(including macroangiopathy and microangiopathy).Strain and strain rate imaging combined with cold pressor test(CPT) were carried out in these two groups.Maximum of circumferential strain(CSmax) and circumferential strain rate(CSRmax) of brachial artery were measured,which were supplied by automatic analysis software.Reserve of circumferential strain(RCS) and circumferential strain rate(RCSR) were calculated.It took six months for each patient to take medicines of reducing blood sugar.Then RCS and RCSR of brachial artery were calculated again.Parameters were compared with inter-and intra-groups.Results:RCS and RCSR of brachial artery after therapy were higher than these before therapy in control group(P<0.05).There were no significant differences between RCS and RCSR of brachial artery before therapy and that after therapy in case group(P>0.05).RCS and RCSR of brachial artery in case group were lower those in control whatever before and after therapy(P<0.05).Conclusion:The protection of medicines of reducing blood sugar on endothelial function of brachial artery in new diabetic patients without vascular complications is better.

关 键 词：肱动脉 内皮功能 应变和应变率成像 2型糖尿病 降糖药物 

分 类 号：R58[医药卫生—内分泌]