苯丙氨酸解氨酶生物传感器线性化的研究  

Study on linearization of phenylalanine ammonia-lyase biosensor

作　　者：周真[1] 贺长水[1] 

机构地区：[1]哈尔滨理工大学测控技术及通讯工程学院,黑龙江哈尔滨150040

出　　处：《哈尔滨工业大学学报》2005年第8期1085-1086,1112,共3页Journal of Harbin Institute of Technology

基　　金：哈尔滨市科技攻关项目(9914211150)

摘　　要：针对苯丙氨酸解氨酶的新型酶生物传感器非线性特性,依据最小二乘法理论,采用最优化技术,建立了标定最佳拟合直线的数学模型,编写了数据拟合程序,实际运行结果表明,该方法克服了生物传感器校正传统方法拟合准确度低的缺点.A novel phenylalanine ammonia-lyase biosensor has been developed for the detection of the genetic disorder, Phenylketonuria in clinic. To solve the non-linear problem of a biosensor, the least square method and the optimum technique have been applied to build a mathematical model to evaluate the optimum fitting straight. The related computer-calculating program is also described. Finally, the experimental results have shown that the new method described can solve the low accuracy problem persist in other conventional fitting methods.

关 键 词：生物传感器 苯丙氨酸解氨酶 线性化 最佳拟合直线 

分 类 号：TH832.3[机械工程—仪器科学与技术]