DNA微阵列技术在细菌感染后宿主反应研究中的应用  

Studying the Host Response to Infection of Pathogenic Bacteria by DNA Microarray

作　　者：李霆[1] 王恒樑[1] 黄留玉[1] 黄翠芬[1] 

机构地区：[1]军事医学科学院生物工程研究所,北京100071

出　　处：《生物技术通讯》2005年第4期441-444,共4页Letters in Biotechnology

摘　　要：感染性疾病是病原微生物和宿主紧密相互作用的结果。深入理解宿主对病原微生物感染发生反应的分子基础是预防感染性疾病发生和组织损伤的必要条件。本文通过介绍体内、体外2种感染模型中宿主对细胞内和细胞外致病菌感染后的基因表达谱变化,简述了DNA微阵列技术在病原菌-宿主相互作用中宿主反应研究中的应用。The infectious disease is result of an intimate interaction between pathogen and host. A better understanding of molecular basis on host response to pathogen and its product is a prerequisite to prevent infection and issue damage. In this review, the application of DNA microarray in the study of host response induced by infection with pathogenic bacteria was briefly introduced through describing the change of gene expression profiling of host, which was infected by intracellular or extracellular pathogenic bacteria in in vivo or in vitro model.

关 键 词：DNA微阵列 病原菌 宿主反应 

分 类 号：Q789[生物学—分子生物学]