甘草黄酮类化合物对酪氨酸酶单酚酶的抑制  

Inhibitory Effects of Several Licorice Flavonoids on the Monophenolase Activity of Tyrosinase

作　　者：傅博强[1] 李欢[1] 王小如[1] LEE Frank SC 

机构地区：[1]厦门大学化学化工学院化学系现代分析科学教育部重点实验室,厦门361005 [2]国家海洋局第一研究所环境与生命过程中物质迁移与反应机理研究室

出　　处：《天然产物研究与开发》2005年第4期391-395,共5页Natural Product Research and Development

基　　金：国家自然科学基金重点项目(20235020)

摘　　要：研究了甘草中四种黄酮类化合物甘草甙、异甘草素葡萄糖芹菜甙、异甘草甙和甘草查耳酮甲对酪氨酸酶单酚酶活性的抑制。结果表明异甘草素葡萄糖芹菜甙、异甘草甙和甘草查耳酮甲的IC50分别为0.072mM,0.038mM,0.0258mM,它们都属于竞争性抑制剂,甘草甙没有抑制活性。研究表明,异甘草素葡萄糖芹菜甙、异甘草甙和甘草查耳酮甲可以作为潜在的美白化妆品添加剂。The inhibitory effects of several licorice flavonoids including liquirifin, licuraside, isoliquiritin and licochalcone A on the monophenolase activity of tyrosinase were studied. The results indicated that the IC50 values of hcuraside, isollquiritin and licochalcone A were 0. 072 mM, 0. 038 mM, 0. 0258 mM, respectivdy, and they are all competitive inhibitors. These flavonoids have the potential to be further devdoped into effective skin whitening agents. Different from the above flavonoids, no inhibitory activity was observed for liquiritin.

关 键 词：甘草 黄酮 酪氨酸酶 抑制 

分 类 号：R282.71[医药卫生—中药学]