微波促L-苯丙氨酸消旋反应研究  

Microwave-assisted Rapid Racemization of L-Phenylalanine

作　　者：刘毅[1] 钱绍松[1] 李加友[1] 郭丽芸[1] 贾晓娟[1] 焦庆才[1] 

机构地区：[1]南京大学生命科学学院医药生物技术国家重点实验室,南京210093

出　　处：《化工进展》2005年第8期893-896,900,共5页Chemical Industry and Engineering Progress

基　　金：国家技术创新基金(No.02CJ130116)资助。

摘　　要：介绍了微波促L苯丙氨酸消旋反应是一种新的可适合于工业化的生产方法,具有对环境友好的优点。使用微波作为热源不仅可加速反应和节约能源,也可提高反应的收率和产品的纯度。本方法确定了在微波辐射下,以1.0mol/L氢氧化钠水溶液替代低级脂肪酸作为反应溶剂,用物质的量比为0.10的水杨醛为催化剂,L苯丙氨酸可以快速消旋;在此条件下,消旋反应随微波辐射功率的提高而加快,在66%输出功率下反应已接近最大反应速率。从实验中得出微波促L苯丙氨酸消旋的反应是一级不可逆反应。考察了此消旋反应的影响因素,同时讨论了微波作用下L苯丙氨酸的消旋反应机理。A practical method for the racemization of L- Phenylalanine by microwave irradiation was developed. Compared with the conventional methods of racemization, microwave dielectric heating promoted the racemization of L - Phenylalanine, leading to a significant increase in reaction rates. There are two main advantages： （1） The whole process of racemization by this method can be completed within circa 1 h in the medium of 1.0 mol/L NaOH under reflux conditions for 1 h in the presence of 0.10 molar equivalent of salicylaldehyde by using 66% power of microwave irradiation; （2） It is an economical, convenient and environmentally acceptable way to racemize L-Phenylalanine. The factors influencing racemization were investigated. The racemization was found to follow first- order reaction kinetics.The mechanism of racemization was discussed.

关 键 词：L-苯丙氨酸 D-苯丙氨酸 消旋 微波辐射 过热效应 

分 类 号：TQ464.7[化学工程—制药化工] O621.22[理学—有机化学]