硫酸阿米卡星注射液含量的测定方法研究  

Study on the Determination of Amikacin Sulfate Injection

作　　者：张幸生[1] 何丽芳[1] 石东方[2] 

机构地区：[1]深圳职业技术学院,广东深圳518055 [2]黄石理工学院医学院,湖北黄石435000

出　　处：《时珍国医国药》2005年第9期938-939,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的:建立硫酸阿米卡星注射液的含量测定方法.方法:采用旋光法和抗生素微生物检定法测定硫酸阿米卡星注射液含量.结果:硫酸阿米卡星注射液浓度在1～20 mg/ml范围内与其旋光度呈良好线性关系,回归方程:y=7.892 9x-0.035 6,r=0.999 9,平均回收率98.92 %,RSD为0.42%(n=5).结论:与抗生素法相比旋光法更简便易行,结果准确,可作为该制剂的检验方法.Objective ：To determine the content of Amikacin Sulfate Injection. Methods： Polarimetric analysis and Antibiotic microorganism was used for determine the content of Amikacin Sulfate Injection. Results：The linear range of Amikacin Sulfate Injection lay between 1-20 mg/ml. The regression equation： C=7.892 9a-0.035 6,r=0.999 9. The average recovery rate was 98.92% with an RSD of 0.42%. Conclusion：Compare width Antibiotic Microbial method, Polarimetry is easy to operate, with accurate and reliable results. It is therefore suitable for the quality control analysis of Amikacin Sulfate Injection.

关 键 词：旋光法 抗生素微生物检定法 硫酸阿米卡星注射液 含量测定 

分 类 号：R927.2[医药卫生—药学]