不同流量改良超滤法的临床应用  

Clinical Application of High Flow Rate Modified Ultrafiltration

作　　者：王伟[1] 朱德明[1] 徐羽中 蒋黎敏[2] 黄惠民[1] 沈立松[2] 

机构地区：[1]上海第二医科大学附属新华医院上海儿童医学中心小儿心胸外科 [2]上海第二医科大学实验诊断中心,上海200127

出　　处：《中国胸心血管外科临床杂志》2005年第4期258-261,共4页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

摘　　要：目的探讨高流量改良超滤的临床应用效果及其对炎症反应的影响。方法40例先天性心脏病患者用随机数字表法分为两组,常规改良超滤(CMUF)组和高流量改良超滤(HMUF)组,每组20例。观察超滤时间、滤液量、红细胞压积(HCT)和循环指标变化,并检测肿瘤坏死因子和白细胞介素6的浓度。结果40例患者均顺利完成手术,术毕HMUF组超滤时间(7.83±0.75min)短于CMUF组(13.86±1.95min,P<0.01),HMUF组滤出液量(440.00±91.86ml)多于CMUF组(372.22±56.52ml,P<0.01)。两组HCT、循环指标和术后炎症因子浓度的变化均无统计学意义。结论HMUF用于小儿体外循环后安全有效,且可以明显缩短超滤时间。Objective To compare the clinical effect between high flow rate modified ultrafiltration （HMUF） and conventional modified ultrafiltration（CMUF）, and the effect on hemodynamic data and inflammatory mediators. Methods Forty children were divided into two groups with random number table, HMUF group and CMUF group, 20 cases each group. Hematocrit （HCT） and hemodynamic changes were recorded and the concentration of tumor necrosis factor （TNF） and interleukin 6 （IL-6） were measured. Results The operations were done uneventfully with moderate hypothermia cardiopulmonary bypass in 40 patients. Duration of ultrafiltration of HMUF group （7.83±0. 75 min） was less than that of CMUF group （13.86±1.95 min, P〈0.01）. The volumes ultrafiltrated of HMUF group （440.00±91.86ml） was more than that of CMUF group （372.22±56.52ml, P〈0.01）. There are no significant differences about the hemodynamic data, HCT, TNF and IL-6 between two groups. Conclusion The HMUF is safe and efficient,when it was used after pediatric cardiopulmonary bypass, the duration of ultrafiltration can be shortened significantly.

关 键 词：高流量改良超滤 先天性心脏病 儿童 

分 类 号：R726.5[医药卫生—儿科]