白细胞滤器在体外循环中的应用进展  

Development of Leukocyte Depletion Filter During Cardiopulmonary Bypass

作　　者：杜磊[1] 周棱[1] 李崎[1] 邓硕曾[1] 

机构地区：[1]四川大学华西医院麻醉科,成都610041

出　　处：《中国胸心血管外科临床杂志》2005年第4期279-282,共4页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：国家自然科学基金青年基金资助项目(30400439)~~

摘　　要：白细胞激活、黏附、释放是导致体外循环(CPB)后发生各种并发症的重要原因之一,因此使用白细胞滤器能减少心、肺、脑等器官功能障碍。而目前使用的白细胞滤器的设计和滤膜的生物相容性等仍存在一些问题尚待改进。由于CPB后白细胞对机体的损伤起主导作用,因此,白细胞滤器研究成熟后可成为预防、治疗CPB导致的非感染性炎性反应的重要方法,而广泛应用于临床。The increased morbidity and mortality following cardiopulmonary bypass （CPB） may be due to the development of systemic inflammatory response syndrome （SIRS）. Leukocyte, especially neutrophil, plays a crucial role in SIRS during and after CPB, so the leukocyte removal by filtrations appears to be a logical anti-inflammatory strategy. Many articles reported that leukocyte depletion filter can decrease the potential adverse effects during CPB and reduce the morbidity and mortality following CPB. But the protective effects of the filter varied greatly from paper to paper. This may be due to the different design and biocompatibility of the filter at present, But, because the leukocyte plays a central role in SIRS, leukocyte depletion filter would be an important apparatus in therapy of noninfectious inflammation induced by CPB after it was improved.

关 键 词：体外循环 白细胞 白细胞滤器 

分 类 号：R654.1[医药卫生—外科学]