三仁汤对脾胃湿热证、湿偏重证大鼠胃动素、胃泌素作用的实验研究  

An Experimental Study of Sanren Tang on Motilin and Gastrin in Damp - Heat and Dominant Damp Syndromes of Spleen - Stomach of Rats

作　　者：文小敏[1] 廖荣鑫[1] 彭胜权[2] 林培政[2] 钟嘉熙[2] 史志云[2] 

机构地区：[1]南方医科大学 中医药学院,广东广州510515 [2]广州中医药大学 温病教研室,广东广州510405

出　　处：《新中医》2005年第9期94-95,共2页New Chinese Medicine

基　　金：广东省中医药管理局资助课题(编号:1040092)

摘　　要：目的:观察三仁汤对脾胃湿热证、湿偏重证大鼠模型血液中胃动素(MTL)、胃泌素(GAS)的调控作用。方法:将32只大鼠随机分为4组各8只。正常对照组:正常温、湿度下予以普通饲料喂养;湿热组:在湿热环境下予以肥甘饮食饲料喂养;湿偏重组:在湿热组饲养基础上灌服北京产二锅头;三仁汤组:在湿偏重组饲养基础上予以三仁汤。采用放免法测定各组大鼠血液中MTL、GAS的变化。结果:MTL、GAS湿热组、湿偏重组与正常对照组、三仁汤组比较,差异均有非常显著性意义(P<0.01);湿偏重组与湿热组比较,差异有非常显著性意义(P<0.01);三仁汤组与正常对照组比较,差异无显著性意义(P>0.05)。结论:三仁汤能对抗湿热证大鼠模型血浆胃动素的升高作用,亦具有调节湿热证大鼠模型血浆胃泌素低下的功能。Objective： To observe the regulative action of Sanren Tang （ST） on motilin （MTL） and gastrin （GAS） in damp- heat and dominant damp syndromes of spleen- stomach of rats. Methods： 32 rats were allocated to 4 groups （each group 8 rats） randomly. The normal control group （NCG） was fed by general feed in normal room termperature and humidity; Damp- heat group（DHG） by greasy feed in wet and hot environment; Dominant damp group（DDG） by greasy feed and rice wine; ST group（STG） by greasy feed . rice wine and ST. The changes of MTL and GAS of blood were determined by radioimmunoassay. Results： The MTL and GAS of DHG and DDG comparied with NCG and STG showing （ P 〈 0.01 ）; DDG comparied with DHG showing （ P 〈 0.01 ）; STG comparied with NCG showing （ P 〉 0. 05） . Conclusion： ST possesses the action for counteracting the increase of plasma MTL in models of damp- heat syndrome and regulating the decrease of plasma GAS in rats.

关 键 词：三仁汤 脾胃湿热 湿重于热 促胃动素 胃泌素类 疾病模型 动物 大鼠 

分 类 号：R285.5[医药卫生—中药学] R256.3[医药卫生—中医学]