超声评价糖耐量低减患者血管内皮舒张功能及其与肥胖的关系  

Ultrasonographic evaluation on brachial endothelial function in patients with impaired glucose tolerance and the relationship of overweight

作　　者：马红[1] 刘爱玲[2] 刘志远[1] 杨丽娟[1] 

机构地区：[1]武警河南总队医院特检科,河南郑州450052 [2]河南省军区门诊部超声科,河南郑州450003

出　　处：《武警医学院学报》2005年第5期346-349,F0002,共5页Acta Academiae Medicinae CPAPF

基　　金：武警总部后勤部科研项目(WKH2002035)

摘　　要：[目的]研究糖耐量低减患者血管内皮舒张功能。[方法]采用高分辨率超声测定糖耐量低减伴超重或肥胖患者(Ⅰ组)及正常体重患者(Ⅱ组)血流介导的肱动脉内皮依赖性血管舒张和硝酸甘油介导的非内皮依赖性血管舒张。[结果]Ⅰ组、Ⅱ组内皮依赖性血管舒张功能较正常对照组降低(均为P<0．001);Ⅰ组较Ⅱ组降低(P<0．05);硝酸甘油介导的非内皮依赖性血管舒张各组间无差异(P>0．05)。多因素线性相关性分析,糖耐量低减患者血管内皮依赖性舒张功能损伤和血糖、甘油三酯、体质量指数呈明显负相关。[结论]糖耐量低减患者血管内皮依赖性舒张功能损伤并且伴超重或肥胖者愈重。Using high resolution ultrasound, the dilation of brachial artery during reactive hyperaemia （with increased flow causing endothelium-dependent dilatation） and after sublingual Nitroglycerin （NTG, causing endothelium-independent dilation） was measured in 69 subjects： 24 healthy volunteers, 25 impaired glucose tolerance patients with overweight （group Ⅰ） and 20 patients without overweight （group Ⅱ）. [Results] In group Ⅰ and group Ⅱ, flow-mediated dilatation （FMD） decreased significantly comparison with the healthy control group （P 〈 0.001）. FMD in group Ⅰpatients was significantly lower than that in group Ⅱpatients （ P 〈 0.05）. The dilation by NTG did not differ significantly among three groups （P 〉 0.05）. Multiple regression analysis showed that endothelial dysfunction was significantly correlated with glucose （γ =- 0.43, P 〈 0.001）, triglyceride （TG） （γ = - 0.41, P 〈 0.001） and body mass index （BMI） （γ= -0.28, P 〈 0.01）. [Conclusion] The endothelium-dependent vasodilation in patients with IGT was redueed and became more serious with increase of BMI

关 键 词：糖耐量低减 内皮功能 高频超声 体质量指数 

分 类 号：R589.1[医药卫生—内分泌]