小檗胺的心血管药理作用研究进展  

Progress of Cardiovascular Pharmacologic Study on Berbamine

作　　者：郭治彬[1] 付金国[1] 

机构地区：[1]江西医学院第一附属医院心血管内科,南昌330006

出　　处：《中国中西医结合杂志》2005年第8期765-768,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：江西省卫生厅科技计划资助课题(No.0301027)

摘　　要：小檗胺是从小檗科小檗属植物细叶小檗等中草药植物中提取的一种双苄基异喹啉生物碱,有抗心律失常、抗心肌缺血、扩血管降压、降低心功能和心率、抗血栓等心血管药理作用,其中小檗胺的抗心律失常作用研究最为深入,它可通过抑制钠、钾、钙等离子通道、负性频率和负性传导作用、提高心肌舒张期兴奋阈值、延长心肌有效不应期而起到显著的抗心律失常作用,作为新型抗心律失常中草药、植物药等研究方向,值得进一步的研究和开发。Berbamine （molecular formular C37H40 N2O6 ） is a bi-benzle-isoquinolyl alkaloid extracted from Berberis poiretil Schneid （genus of Berberis, family of Beridaceae）, a kind of Chinese plants. In aspect of cardiovascular pharmacology, berbamine shows actions of anti-arrhythmia, anti-myocardial ischemia, vasodilatating to lower blood pressure, and antithrombosis, it could lower heart function and heart rate. Study on its anti-arrhythmia was the deepest one. The significant anti-arrhythmia action can be achieved by inhibiting ionic channels of sodium, potassium, calcium, etc. , negative frequency and negative transduction, improving the diastolic excitation threshold of myocardium, prolonging effective refractory period of myocardium searches on new type of antiarrhythmic herbs and herbal drugs, the study on berbamine is search and development, As a direction of re worthy of further research and development,

关 键 词：心血管疾病 小檗胺 心律失常 药理学 心血管药理作用 抗心律失常作用 抗心肌缺血 中草药植物 异喹啉生物碱 小檗属植物 

分 类 号：R285[医药卫生—中药学]