抗乙肝转移因子结构与性质的初步研究  

Studies on structure and properties of anti-HBV specific TF

作　　者：陈艳菊 林琳[2] 刘刚[3] 张骞[3] 赵宏侠 林永齐[3] 

机构地区：[1]大连百利天华制药有限公司,辽宁大连116033 [2]大连医科大学生化室,辽宁大连116027 [3]吉林大学生命科学学院,吉林长春130023

出　　处：《中国生化药物杂志》2005年第4期230-232,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的从抗乙肝转移因子溶液中分离出有效组分并研究其结构与性质。方法用SephadexG25柱色谱分离纯化,用化学分析法和物理学方法研究其结构与性质。结果活性组分的多肽相对分子质量为3200左右,含有15种氨基酸和腺嘌呤核苷酸。结论抗乙肝转移因子活性组分是低分子核苷酸与多肽组成的复合物。Purpose To separate components from anti-HBV Specifce TF and to study their structural nature. Methods Anti-HBV specific TF was separated and purified by Sephadex G 25 columen chromotograpy, its structural nature was studied by chemical analysis methods and physical analysis methods. Results We obtained active comoponent, and its molecular wight was about 3 200. It contained 15 kinds of amino acidies and adenine mononucleotide. Conclusion The active component of anti-HBV Specific TF was a small molecule that consisted of nucleotide and polypeptide.

关 键 词：抗乙肝转移因子 分离纯化 结构 性质 

分 类 号：TQ464[化学工程—制药化工] R512.62[医药卫生—内科学]