复方大青叶注射液生产工艺的研究  

Study on the productive process of Compound Folium Isatidis Injections

作　　者：沈兆军 刘铭传 潘春华 

机构地区：[1]鲁南制药集团股份有限公司,临沂276005

出　　处：《齐鲁药事》2005年第8期485-486,共2页qilu pharmaceutical affairs

摘　　要：目的对复方大青叶注射液的生产工艺进行改进,降低毒、副作用,达到安全有效的目的。方法通过正交试验对加水量,提取时间,提取次数进行因素考察,验证工艺路线的可行性。结果采用水提醇沉法提取,条件为加水10倍量、煎煮3次、每次为1·5h,在制剂中采用两步醇沉两步水沉,加入适量活性炭,脱色。结论该工艺充分考虑经济性、可操作性,适用于复方大青叶注射液的大生产。Objective To improve the process of Compound Folium Isatidis Injections,lower its poison and side effects,attain the safe and operative goal.Methods The volume of water,extract time and the number of times of extract were studied to verify the possibility of craft route by orthogonal design. Results Using water-extraction and alcohol-precipitation to extract, 10 times water, 1.5 hours of three times needed, In the process of preparations ,twice alcohols-precipitation and twice water-precipitation were adopted. It can make the color shallow by adding activity carbon.Conclusion This＇ craft is considered on the economy and operation.This experimental method is suitable to the productive preparation of Compound Folium Isatidis Injections.

关 键 词：复方大青叶注射液 正交试验 提取工艺 生产工艺 均匀设计 

分 类 号：TQ460.6[化学工程—制药化工]