多巴胺D2受体-141C Ins/Del多态与海洛因渴求的关系  

Relationship between DRD2 - 141C Ins/Del Polymorphism and Heroin Craving

作　　者：邵春红[1,2] 江开达[3] 李一峰[4] 赵敏[3] 林灵[4] 徐一峰[3] 王秋颖[3] 

机构地区：[1]复旦大学附属华山医院精神科 [2]上海市精神卫生中心,上海200030 [3]上海市精神卫生中心 [4]复旦大学生命学院遗传所

出　　处：《中国临床心理学杂志》2005年第3期309-311,共3页Chinese Journal of Clinical Psychology

基　　金：上海市卫生局科技发展基金(项目号:01417)

摘　　要：目的:探讨多巴胺D2受体-141CIns/Del基因多态与线索诱发海洛因渴求程度的关系。方法:对戒断期380名海洛因依赖者实施线索诱发渴求实验,采用PCR-RFLP技术检测其DRD2-141CIns/Del基因多态,比较不同基因型与线索诱发海洛因渴求程度的关系。结果:DRD2-141CIns/Del三种多态基因型中,线索暴露前后海洛因渴求程度的差异均无显著性(P>0.05)。结论:DRD2-141CIns/Del基因多态可能与线索诱发海洛因渴求的易感性无关。Objective： To explore the relationship between DRD2 -141C Ins/Del polymorphism and heroin craving. Methods： 380 heroin addicts who were under abstinence were given the cue-elicited heroin craving experiment. And then we detected the polymorphism of DRD2-141C Ins/Del for them by using PCR-RFLP. We compared the relationship between genotypes of DRD2-141C Ins/Del and heroin craving before and after cue exposure. Results： No significant difference has been found between heroin craving before and after cue-exposure in three genotypes of DRD2-141C Ins/Del. Conclusion： D2 receptor gene -141C Ins/Del polymorphisms may have no association with the susceptibility of heroin craving.

关 键 词：海洛因依赖 线索 渴求 多巴胺D2受体 多态性 

分 类 号：B845.4[哲学宗教—心理学]