β_2肾上腺素受体基因多态性与支气管哮喘的相关性研究  

Study on the Relationship between the Genetic Polymorphisms of β_2-Adrenergic Receptor Gene and Asthma

作　　者：潘永平[1] 周世良[1] 况九龙[1] 饶纬华[1] 

机构地区：[1]江西医学院第二附属医院呼吸内科,江西南昌330006

出　　处：《江西医学院学报》2005年第4期44-47,共4页Acta Academiae Medicinae Jiangxi

摘　　要：目的探讨β2肾上腺素受体(β2AR)基因多态性与支气管哮喘发病及其严重程度的相关性。方法采用扩增阻滞突变系统聚合酶链反应(ARMS-PCR)技术来检测β2AR基因16和27位点基因型在45例哮喘患者与他们的健康一级亲属(对照组)中的频率分布。结果(1)哮喘组16位点Gly/Gly基因型频率为31%,健康对照组中频率为11%,两者比较差异有显著性(P<0.01);而27位点两组各基因型频率分布无显著性差异(P>0.05);(2)轻度哮喘患者16位点Gly/Gly基因型频率为9.5%,中重度哮喘患者频率为37.5%,两者比较差异有显著性(P<0.01),而27位点两组各基因型频率分布无显著性差异(P>0.05)。结论β2肾上腺素受体(β2AR)基因多态性与哮喘发病及其严重程度之间有一定的关系,可能是哮喘的易感基因之一。Objective To investigate the correlation between the genetic polymorphisms of β2- adrenergic receptor gene and the development and severity of asthma. Methods The 16 and 27 polymorphisms of β2-adrenergic receptor gene was genotyped by amplification refractory mutation system-polymerase chain reaction（ARMS-PCR） in 45 asthmatic subjects and their healthy direct relatives. Results （1） The frequency of Gly/Gly genotype in 16 site was 31% in asthmatic group and 11% in control group with a significant difference between two groups（P〈0.01）; there was no significant difference in the distributions of the genotypes in 27 site between two groups（P〉0.05）. （2） The frequency of Gly/Gly genotype in 16 site was 9.5% in the patients with mild asthma and 37.5% in the patients with moderate severe asthma （P〈0.01）; there was no significant difference in the distributions of the genotypes in 27 site of two groups（P〉0.05）. Conclusion There is a certain correlation between the genetic polymorphisms of β2-adrenergic receptor gene and the development and severity of asthma;β2-adrenergic receptor gene may be one of susceptibility genes.

关 键 词：哮喘 β2肾上腺素受体基因 多态性 

分 类 号：R562.25[医药卫生—呼吸系统]