大剂量银杏叶胶囊对家犬血清中抗氧化指标的影响  

Effect of Excessive Ginkgo Leaves Capsule on Antioxidants Level in Serum of Dogs

作　　者：田蜜[1] 冯高谦[2] 张磊[2] 黄沛力[2] 

机构地区：[1]首都医科大学实验中心 [2]首都医科大学公共卫生与家庭医学学院

出　　处：《首都医科大学学报》2005年第4期441-442,共2页Journal of Capital Medical University

摘　　要：目的了解大剂量银杏叶胶囊对家犬血清中抗氧化指标的影响.方法给家犬口服200倍临床剂量的银杏叶胶囊,分别测定了给药2 d内8个时间点血清中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、脂质过氧化物(LPO)的活性或含量.结果给药后家犬血清中SOD的活性较给药前降低,给药后7～24 h降低明显(P＜0.01);GSH-Px的活性变化较小,只在给药后10 h明显降低(P＜0.01);LPO的含量在给药5 h以内降低(P＜0.01),7～10 h增加,10 h明显增加,与给药前相比差异有统计学意义(P＜0.01).结论动物口服大剂量银杏叶制剂后,机体处于氧化应激状态,抗氧化能力减弱.Objective To study the effect of excessive dose of Ginkgo biloba L leaves capsule on antioxidants level in serum of dogs. Methods Six dogs were fed excessive dose of Ginkgo biloba L leaves capsule. SOD and GSH-Px in serum of dogs＇ were measured by methods of ultraviolet visible spetrophotometry ; LPO were measured by means of fluorescence spectroscopy methods. Results The activity of SOD after capsules taken were lower than that before capsule feeding. Seven to 10 h after capsules taken SOD＇s level was decreased significantly（ P 〈 0.01 ）. GSH-Px＇ s level was decreased 10 h after feeding（ P 〈 0.01 ）. LPO was decreased in 5 h and increased in 7- 12 h after capsules taken（ P 〈 0.01）. Conclusion The animals are in state of oxidetine stree and ability of antioxidant of dogs is decreased after excessive ginkgo biloba L leaves capsule was taken.

关 键 词：银杏叶 家犬 抗氧化 血清 

分 类 号：R285.5[医药卫生—中药学]