内皮型一氧化氮合酶基因G894T多态性与血压变化的关系  

Association of G894T Polymorphism of Endothelial Nitric Oxide Synthase Gene with Blood Pressure Change

作　　者：李东宝[1] 华琦[1] 皮林[1] 

机构地区：[1]首都医科大学宣武医院心血管内科

出　　处：《首都医科大学学报》2005年第4期454-456,共3页Journal of Capital Medical University

基　　金：首都医学发展基金(2002-2007)资助项目

摘　　要：目的探讨内皮型一氧化氮合酶(eNOS)基因G894T多态性与中国汉族人原发性高血压(以下简称高血压,EH)的相关性。方法采用多聚酶链反应结合限制性内切酶片段长度多态性分析方法,检测310例高血压患者(高血压组)和151例健康人(对照组)的eNOS基因G894T多态性。结果1)高血压组GT+TT基因型和T等位基因频率显著高于对照组(P<0.05);2)高血压组T等位基因携带者的收缩压(20.07±1.81)kPa〔(150.50±13.56)mmHg〕、舒张压(13.33±0.73)kPa〔(100.01±8.46)mmHg〕和平均动脉压(15.58±1.05)kPa〔(116.84±7.84)mmHg)〕均高于GG基因型携带者〔(19.59±1.62)kPa〔(146.96±12.18)mmHg〕、(12.99±1.06)kPa〔(97.44±7.98)mmHg〕、(15.19±1.0)kPa〔(113.95±7.49)mmHg〕〕,2组比较差异有统计学意义(P<0.05)。结论eNOS基因G894T多态性的T等位基因是中国汉族人高血压的重要危险因素之一。Objective To investigate the association of the G894T polymorphism of endothelial nitric oxide synthase （eNOS） gene with blood pressure change in Chinese than nationality population. Method Polymerase chain reaction combined with restriction enzyme digestion was used to detect the polymorphism of eNOS gene in 151 normotensive individuls as control（NT） and 310 hypertensive patients（EH）. Results The frequencies of T allele and GT ＋ TT genotype in EH were significantly higher than in NT group;Systolic blood pressure, Diastolic blood pressure, Mean of arterial blood pressure of T allele of eNOS gene G894T polymorphism （20.07± 1.81）kPa[（150.50 ± 13.56）mmHg], （13.33 ± 0.73）kPa[（100.01 ± 8.46）mmHg], （15.58 ± 1.05） kPa[ （ 116.84 ± 7.84）mmHg] were higher than that of GG genotype [ （ 19.59 ± 1.62）kPa[ （ 146.96 ± 12.18）mmHg], （ 12.99 ± 1.06）kPa[（97.44±7.98）mmHg], （15. 19±1.0）kPa[（113.95±7.49）mmHg]]. Conclusion The T allele of G894T polymorphism of eNOS gene is one of risk factors in Chinese hypertensive population.

关 键 词：高血压 一氧化氮合酶 多态性 一氧化氮 

分 类 号：R544.1[医药卫生—心血管疾病]