辛伐他汀强化降脂治疗对不稳定心绞痛患者血浆高敏C-反应蛋白水平的影响  

Influence of Reinforced Lipid-lowering Treatment with Simvastatin on the Plasma Concentration of High-Sensitivity C-Reactive Protein in Patients with Unstable Angina Pectoris

作　　者：曹树军[1] 崔亮[2] 王金波[1] 王立中[1] 

机构地区：[1]北京市大兴区人民医院心内科,北京102600 [2]首都医科大学附属北京朝阳医院心脏中心,北京100020

出　　处：《中国医药导刊》2005年第4期279-280,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:研究常规降脂(辛伐他汀20mg/d)和强化降脂(辛伐他汀40mg/d)治疗1月后不稳定心绞痛(UAP)患者血浆高敏C反应蛋白(hs-CRP)浓度的变化,探讨短期强化降脂治疗对hs-CRP水平的影响.方法:选取不稳定心绞痛患者76例,均经冠状动脉造影证实,被随机分为常规降脂治疗组和强化降脂治疗组.在接受同样规范化治疗基础上,常规降脂组和强化降脂组分别接受辛伐他汀20mg/d和40mg/d治疗1月,测定治疗前、后血浆hs-CRP浓度.结果:降脂治疗1月后,常规降脂组治疗后Hs-CRP浓度与治疗前无明显变化,而强化降脂组治疗后Hs-CRP浓度较治疗前显著下降(P<0.05),并且明显低于同期常规降脂治疗组(P<0.05).血浆Hs-CRP浓度降低与血脂变化无显著相关.结论:强化降脂治疗可以在短期内有效降低不稳定心绞痛患者hs-CRP浓度.Objective： To study the changes of plasma high - sensitivity C - reactive protein （hs - CRP） concentrations in patients with unstable angina pectoris （UAP） after one - month treatment with simvastatin 20rag or 40rag per day, and explore the influence of reinforced lipid - lowering therapy on hs- CRP in short term.Methods： 76 eases of unstable angina pectoris diagnosised by angiocardiography were randomly divided into two groups to accept either simvastatin 20rag per day as routine lipid - lowering group （ROU group, n = 38） or simvastatin 40mg per day as reinforced lipid - lowering group （REI group, n = 38） of one month at the base of routine therapy. The concentrations of plasma Ks - CRP of all patients were measured before and after themy .Results： After one month, the plasma KS - CRP concentrations did not significantly changed in ROU group comparing to the baseline, while in REI group, the KS - CRP concentrations were siglfificandy decreased, and were evidently lower than that of patients in ROU group at the.same period. The reduction of plasma hs - CRP concentration was not significantly related to the changes of plasma lipid levels, Condusion： Lipid - lowering therapy with simvastatin 40mg per day can effectively reduce the plasma KS - CRP concentrations in patients with UAP in short - term.

关 键 词：辛伐他汀 强化降脂 不稳定心绞痛 血浆 高敏C-反应蛋白 阿司匹林 

分 类 号：R541.4[医药卫生—心血管疾病] R972[医药卫生—内科学]