人类BMP-2基因启动子位置的预测  

Pridiction of human BMP-2 Promotor

作　　者：胡飞[1] 周磊[1] 张雪洋[1] 吴王喜[1] 

机构地区：[1]广东省口腔医院南方医科大学附属口腔医院,主治医师广东510280

出　　处：《中华老年口腔医学杂志》2005年第3期139-141,共3页Chinese Journal of Geriatric Dentistry

基　　金：广东省自然科学基金资助项目(32569)

摘　　要：目的:预测人类BMP-2基因启动子位置和可能的转录因子结合位点。方法:从Genebank中获得BMP-2的全长编码基因,利用firstEF,footprinter和Consite软件对人类BMP-2基因,小鼠BMP-2基因,鸡BMP-2基因的5’侧翼序列进行生物信息学分析。结果:用firstEF软件预测BMP-2基因的启动子区可能位于(-513..57),用footprinter软件证实其位于BMP-2基因的进化保守区,用Consite软件预测可能的转录因子结合位点。结论:(-513..57)为最可能的启动子区。Objective： To predict the promotor position and transcription factor binding sites of human BMP-2 gene. Methods： Complete coding BMP-2 gene sequences were obtained from Genebank. Human BMP-2 gene, mouse BMP-2 gene, and chicken BMP-2 gene were analyzed with firstEF, footprinter and Consite software. Results： The promoter of human BMP-2 gene was located in（-513.57）, which was convinced by footprinter software. Transcription factor binding sites of human BMP-2 gene was predicted by Consite software. Conclusion： The promoter of human BMP-2 gene is located in（-513.. 57）

关 键 词：启动子 生物信息学 人类BMP-2基因 骨质疏松症 

分 类 号：R58[医药卫生—内分泌]