通心络抑制低密度脂蛋白氧化修饰的研究  

A Study on Inhibiting Effect of Tongxinluo on LDL Oxidation

作　　者：龚浠平[1] 李轶[1] 梁德君[1] 张娟[1] 王拥军[1] 

机构地区：[1]首都医科大学附属北京天坛医院神经内科,北京100050

出　　处：《解放军药学学报》2005年第4期255-258,共4页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的探讨通心络对低密度脂蛋白氧化修饰的抑制作用。方法分别以二甲基亚砜和丙丁酚作为对照,采用Cu2+诱导的LDL体外氧化模型,观察通心络对ox-LDL形成的抑制作用。结果丙丁酚和通心络均可以明显的抑制LDL的氧化,并且存在明显的浓度效应关系。结论通心络素可显著抑制ox-LDL的形成。Aim To investigate the antioxidatent effect of Tongxinluo （capsule） on low density lipoprotein （LDL） oxidation. Methods With dimethyl sulfoxide and Probucol as a control respectively, LDL oxidatent model induced by Cu^2＋ and the inhibiting effect of Tongxinluo on ox-LDL were observed. Results We found that Tongxinluo and Probucol had the same antioxidatent effect on LDL oxidation. There was significant concentration-effect relationship between them. Conclusions Tongxinluo could significantly inhibit the production of ox-LDL.

关 键 词：低密度脂蛋白 氧化修饰 通心络 

分 类 号：R965[医药卫生—药理学]