愈肝胶囊的抗鸭乙肝病毒作用研究  

Experimental Study on Anti-DHBV Effect of Yu Gan Capsules

作　　者：谭行华[1] 张爱民[1] 余卫华[1] 岑玉文[1] 张奉学[2] 

机构地区：[1]广州市第八人民医院,广州510060 [2]广州中医药大学热带病医学研究所,广州510405

出　　处：《中药材》2005年第8期679-681,共3页Journal of Chinese Medicinal Materials

基　　金：广东省中医管理局课题(NO.97×307)

摘　　要：目的观察愈肝胶囊抗鸭乙肝病毒作用。方法选1日龄广州麻鸭50只接种病毒,随机分为无环鸟苷200μg/kg,愈肝胶囊6.5g/kg,3.25g/kg及病毒对照组,每日一次口服,分别观察其抗DHBV的作用。试验结束时,取肝组织做病理切片光镜观察。结果愈肝胶囊6.5g/kg组在给药后第5天,第10天和停药后第3天,鸭血清DHBVDNA水平均明显下降,与给药前自身比较及病毒对照组比较,差异均有显著性(P<0.01);3.25g/kg愈肝胶囊组在给药后第3天及停药后第3天与病毒对照组比较有显著性(P<0.05),而与给药前无统计学差异。结论愈肝胶囊具有抗鸭乙肝病毒及改善鸭肝脏炎性病变作用,且具有明显量效关系。Objective： To observe the antiviral effect of Yu Gan capsules against DHBV in ducks, Methods： 50 Guangzhou brown spot ducks were used in this experiment ,After the ducks were infected DHBV, they were divided into four groups at random（ ACV 200 mg/kg group, Yu Gan capsules 6.5 g/kg group, Yu Gan capsules 3.25 g/kg group and virus eontrol group） and Drugs were given by stomach onee a day. Blood samples were taken from eaeh duek and tested for DHBV-DNA＇ s level. Researches left liver tissue were sheared and used for optical analysis. Results： In Yu Gan capsules 6. 5 g/kg group, DHBV-DNA＇ s level in dueks＇ serum decreased on the 5^th and 10^th days after treatment and the 3th day after reeession of treatment, There was a significant difference in the DHBV- DNA＇ s level between the days after treatment and before treatment, there was also significant difference in the DHBV-DNA＇ s level between Yu Gan capsules 6. 5 g/kg group and virus control group（ P 〈0. O1 ）, Whereas, no inhibition effect was found in Yu Gan capsules 3.25 g/kg group. Conclusion： Yu Gan capsules have functions on anti-DHBV in duck.

关 键 词：愈肝胶囊 乙肝病毒 药理作用 鸭乙肝病毒 病毒作用 麻鸭 抗DHBV 肝脏炎性病变 统计学差异 给药前 

分 类 号：R512.6[医药卫生—内科学] R563.1[医药卫生—临床医学]