黄芪甲苷的提取新工艺研究  

Study on New Extraction Technology of Astragaloside Ⅳ

作　　者：孙海燕[1] 关溯[2] 黄民[2] 

机构地区：[1]深圳职业技术学院,深圳518055 [2]中山大学药学院,广州510080

出　　处：《中药材》2005年第8期705-708,共4页Journal of Chinese Medicinal Materials

摘　　要：目的探索CO2超临界萃取法提取黄芪甲苷的可行性及最佳工艺。方法以黄芪甲苷总量为指标,运用CO2超临界萃取法,研究超临界萃取温度、压力、时间、萃取剂流速和夹带剂量对提取率的影响,并与水提法比较。结果CO2超临界萃取法提取黄芪甲苷的最优工艺条件为萃取压力40Mpa,温度45℃,萃取时间2小时,夹带剂为95%乙醇,夹带剂量4ml(95%乙醇)/g(干黄芪粉),CO2流量10kg/kg·h。结论CO2超临界萃取法提取黄芪甲苷方法稳定、提取率高,工艺可行。Objective： To explore the possibility and the optimal extraction technology of astragaloside IV by SFE-CO2. Methods：According the content of astragaloside Ⅳ, the optimum extraction technology parameters such as extraction temperature, pressure, extraction time,velocity of fluid and co-solvent were investigated and the result was compared with that of water extraction. Results： The optimum technical parameters were as follows： Extracting pressure 40 Mpa, temperature 45℃ , extracting time 2h, co-solvent was 95% ethanol and its dosage was 4ml/g, the ratio of CO2 fluid was lOkg/kg ·h. Conclusion： Extraction technology of astragaloside Ⅳ by SFE-CO2 is reliable, stable.

关 键 词：黄芪甲甘 CO2超临界萃取 提取工艺 黄芪甲苷 工艺研究 提取率 CO2流量 萃取温度 萃取压力 萃取时间 

分 类 号：R286.0[医药卫生—中药学] R284.2[医药卫生—中医学]