隔膜引导下血管内皮生长因子复合煅烧骨对骨缺损修复作用的实验研究  

Experimental study on repairing bone defects by membrane technique combined with true bone ceramic and vascular endothelial growth factor

作　　者：周东生[1] 王永会[1] 董宏朋[1] 王鲁博[1] 王伯珉[1] 李连欣[1] 穆卫东[1] 许世宏[1] 

机构地区：[1]山东省立医院创伤骨科,济南250021

出　　处：《中国矫形外科杂志》2005年第17期1319-1322,共4页Orthopedic Journal of China

摘　　要：[目的]研究隔膜引导下VEGF复合煅烧骨(TBC)修复骨缺损的作用,探讨其临床应用前景。[方法]新西兰大白兔80只,建立桡骨干中段10mm骨缺损模型。A组植入e-PTFE膜包绕的VEGF复合TBC,B组植入VEGF复合的TBC,C组植入e-PTFE膜包绕的TBC,D组单纯植入TBC。术后第2、4、6、8和12周行X线、组织学观察,测定骨密度并分析其成骨量。[结果]D组的骨缺损修复效果最差,B、C组中等,A组最佳。A组在各时段上其骨密度测量的结果优于B、C、D组,差异性显著(P<0·01)。[结论]e-PTFE膜包绕的VEGF复合TBC能够更好地修复骨缺损,是一种较为理想的骨组织工程材料,具有良好的临床应用前景。[ Objective] To study the repair effect of VEGF combined with TBC by membrane technique and discuss the potential application of this material at clinic. [ Method ] The whole quantity of experimental animals was eighty New Zealand rabbits, 10 mm bone defect of both rabbits radius was established. Group A： implanted e-PTFE combined with VEGF and TBC; group B： implanted TBC combined with VEGF; group C： implanted e-PTFE combined with TBC; group D： implanted only TBC. At the 2, 4, 6, 8 and 12 week postoperatively, experimental animals underwent X-ray and histology investigation randomly, bone density of the implant were measured. [ Result ] The effect of every group repairing bone defect was evaluated, group D was poor, group B and C was good, group A was excellent. The differences of bone density between group A and group B, C, D were significant in statistics （P 〈 0. 01 ） . [ Conclusion] VEGF-TBC combined with e-PTFE membrane can repair bone defect excellently. It has a good potential application prospect at clinic as a kind of bone tissue-engineering vehicle.

关 键 词：血管内皮生长因子 煅烧骨 膨体聚四氟乙烯膜 膜引导性骨组织再生 骨缺损 骨缺损模型 修复作用 膜引导 复合 实验研 

分 类 号：R687[医药卫生—骨科学]