5-氟尿嘧啶-1-乙酸合铜(Ⅱ)的合成及其与DNA的作用  

The Interactions between 5-fluorouracil-1-acetic Acid and its Capper(Ⅱ)Complex with DNA

作　　者：王志平[1] 张强[1] 宋玉民[2] 黄键[3] 王流芳[3] 

机构地区：[1]兰州大学第二医院泌尿外科研究所,兰州730000 [2]西北师范大学化学化工学院,兰州730070 [3]兰州大学功能有机分子化学国家重点实验室,兰州730000

出　　处：《无机化学学报》2005年第9期1397-1401,共5页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金项目(No.50272027)资助;甘肃省高分子材料重点实验室和西北师范大学A级学科资助

摘　　要：The 5-fluorouracil-1-acetic acid (5FuAA) and its Cu! complex (5FuAACu) were synthesized and the date for the crystal complex was obtained. The interaction of 5-fluorouracil-1-acetic acid (5FuAA) and its Cu! complex (5FuAACu) with DNA was also investigated by using spectral, viscometric, electrochemical and agarose gel electrophoresis methods. The results of interaction with DNA suggest that both 5FuAA and 5FuAACu can bind to DNA in a static electricity attraction mode. But the attraction of 5FuAACu is greater than that of 5FuAA.The 5-fluorouracil-l-acetic acid （5FuAA） and its Cu（Ⅱ） complex （5FuAACu） were synthesized and the date for the crystal complex was obtained. The interaction of 5-fluorouracil-l-acetic acid （SFuAA） and its Cu（Ⅱ） complex （SFuAACu） with DNA was also investigated by using spectral, viscometric, electrochemical and agarose gel electrophoresis methods. The results of interaction with DNA suggest that both 5FuAA and 5FuAACu can bind to DNA in a static electricity attraction mode. But the attraction of 5FuAACu is greater than that of 5FuAA.

关 键 词：5-氟尿嘧啶-1-乙酸合铜(Ⅱ) DNA 静电吸附 

分 类 号：O627.12[理学—有机化学]