离体灌流肾技术检测缺血再灌注对大鼠肾功能和肾血管反应性的影响  

Effects of renal ischemia reperfusion on renal function and renal vascular responsibility in isolated perfused rat kidney

作　　者：王新良[1] 李洪娟[1] 谢菲[1] 陈晓玲[2] 黄善生[2] 

机构地区：[1]河北医科大学第二医院儿科,河北石家庄050000 [2]河北医科大学病理生理教研室,河北石家庄350017

出　　处：《新乡医学院学报》2005年第5期441-443,共3页Journal of Xinxiang Medical University

摘　　要：目的探讨肾缺血再灌注对大鼠肾功能和肾血管反应性的影响。方法应用离体灌流肾(IPK)技术观察肾缺血再灌注(IR)后大鼠IPK肾小球滤过率(GFR)、尿钠排泄指数(FENa)、肾血管阻力(RVR)和肾血管反应性的改变。结果(1)肾IR能够增大RVR、降低GFR,使尿钠排泄增多。(2)肾IR降低了IPK对NE和Ach的反应性。结论肾IR导致大鼠肾功能损伤和肾血管反应性降低。Objective To investigate the effects of renal ischemia reperfusion on renal function and renal vascular responsibility in rats. Methods Isolated perfused kidney （IPK） was used to examine the effects of renal ischemia reperfusion on renal vascular resistance （RVR）, glomerular filtration rate （GFR）, fractional excretion of sodium （FENa） and renal vascular responsibility. Results （.1） renal ischemia reperfusion resulted in increase of RVR, decrease of GFR and increment of FENa（all P〈0.05）; （2）renal ischemia reperfusion decreased the renal vascular responsibility to NE and Ach. Conclusion Renal ischemia reperfusion can damage renal function and reduce renal vascular responsibility.

关 键 词：肾 缺血再灌注 离体灌流肾 肾功能 肾血管反应性 

分 类 号：R692.5[医药卫生—泌尿科学]