心理干预对干扰素-α治疗慢性乙型病毒性肝炎30例疗效及复发的影响  

Effects of psycho-intervention on efficacy and relapse of interferon-alpha for treatment of patients with chronic hepatitis B

作　　者：李桂香[1] 王剑英[2] 李桂琴[3] 

机构地区：[1]新乡医学院一附院感染病科,河南卫辉453100 [2]新乡医学院二附院老年精神科,河南新乡453000 [3]新乡医学院一附院胸外科,河南卫辉453100

出　　处：《新乡医学院学报》2005年第5期518-520,共3页Journal of Xinxiang Medical University

摘　　要：目的分析心理干预对慢性乙型病毒性肝炎(CHB)患者重组干扰素-α2b(rIFN-α2b)疗效的影响。方法CHB患者60例随机分为2组,观察组和对照组各30例,观察组除用rIFN-α2b治疗外加心理干预治疗,对照组单用rIFN-α2b治疗。rIFN-α2b治疗前、结束时用症状自评量表(SCL—90)分别进行心理测试,并相互比较。结果治疗前两组患者均存在严重的心身症状,差异无显著性(P>0.05);治疗后观察组阳性总分低于对照组(P<0.05);随访期末观察组完全应答率高于对照组(P<0.05),而复发率低于对照组(P<0.05)。结论CHB患者抗病毒前心理负担大,存在负性情绪;心理干预能减轻心理负担,且能提高干扰素-α治疗的远期疗效,降低复发率。Objective To observe effect of payehie intervention on recombinant interferon-α2b（rlFN-α2b） therapy in patients with chronic hepatitis B（CHB）. Methods Sixty CHB pateints were randomly divided into two groupa,observation group and control group （each group including 30 patients）. The psychio-intervention combined with rlFN-α2b was carried out in the observation group, the control group treated with single rlFN-α2b.. Psycho-logical test was performed in two groups using SCL-90 and compared pre- and post-treatment. Results Psychological status of 2 groups patients were similar before treatment （P 〉0.05）. The total positive score of payehologieal test in observation group were lower than that in control group （P〈0.05）. The complete response rates in observation group were higher than that in the control group at the end of the follow-up period （P〈0.05）. Relapse rate in observation group were lower than that in control group（P〈0.05）. Conclusion The CHB patients have notable payehologieal and negative moods before treatment. Psycho-intervention can release payehologieal status and improve the long term effectiveness of rIFN-α2b for CHB and decrease relapse.

关 键 词：病毒性肝炎 慢性乙型肝炎 心理治疗 干扰素-α疗效 

分 类 号：R512.62[医药卫生—内科学]