妊娠期肝内胆汁淤积症患者肝功能与围生儿预后的关系  

Relationship between Hepatic Function Index and the Perinatal-prognosis in Intrahepatic Cholestasis during Pregnancy.

作　　者：曹来英[1] 王玉兰[1] 张蔚[1] 周美茜[1] 徐慧[1] 曾洁[1] 

机构地区：[1]武汉大学人民医院妇产科,430060

出　　处：《公共卫生与预防医学》2005年第4期28-30,共3页Journal of Public Health and Preventive Medicine

摘　　要：目的研究妊娠期肝内胆汁淤积症(ICP)患者肝功能与围生儿预后的关系.方法回顾性分析了武汉大学人民医院自1997年4月～2004年12月收治的240例ICP患者的血清TBA、ALT、TBIL与围生儿预后的关系.结果ICP患者TBA、ALT、TBIL水平越高则胎儿窘迫、早产和新生儿窒息的发生率就愈高(P＜0.01),新生儿平均体重就越轻,但血清ALT值升高和羊水粪染之间无显著相关性(P＞0.05).结论对ICP患者进行肝功能部分指标的检测,是监测胎儿预后的一项可靠指标,在妊娠中晚期对产前母婴保健工作有十分重要的意义.Objective To study the relationship between hepatic function index and the perinatalprognosis in ICP. Methods 240 patients with ICP were studied retrospectively. （From April 1994-December 2004）. Results The higher the serum levels of TBA,ALT and TBIL in patients with ICP, the higher incidence of fetal distress, premature labor, low weight birth and asphyxia neonatorum would occur （P〈0. 01）. However,there was no significant relation between the serum level of ALT and meconium-stained amniotic fluid（P〉0.05）. Conclusion The hepatic function of the patients with ICP is a reliable index for monitoring perinatal-prognosis,therefore,this test is of great importance for protecting mother and fetus.

关 键 词：胆汁淤积症 肝功能 羊水粪染 围生儿预后 

分 类 号：R714.146[医药卫生—妇产科学] R722[医药卫生—临床医学]