低抗原配方奶对预防婴儿过敏的前瞻性研究  

A prospective study on the preventive effect of hydrolyzed formula on infantile allergy

作　　者：钱继红[1] 敖黎明[1] 陈冠仪[1] 杨祖菁[1] 王留娣[2] 高美玲 钱晓虎[4] 陆国强[5] 顾擎东 董蔚 郑珠丽[8] 吴圣楣[1] 

机构地区：[1]上海第二医科大学附属新华医院儿科 [2]上海市浦东新区妇幼保健院 [3]上海市奉贤区中心医院 [4]上海市东方医院 [5]上海市第一妇婴保健院 [6]上海市崇明堡镇医院 [7]上海市南翔医院 [8]上海市徐汇区中心医院

出　　处：《上海医学》2005年第8期640-642,共3页Shanghai Medical Journal

摘　　要：目的探讨低抗原配方奶对预防婴儿过敏的作用。方法选择具有过敏家族史的新生儿95名,63名给予母乳和低抗原配方奶喂养(低抗原配方奶组);另32名给予母乳和普通配方奶喂养(普通配方奶组)。结果普通配方奶组在3、6月龄和1周岁时出现湿疹及哮喘性支气管炎的比率均明显高于低抗原配方奶组(P值分别<0.05和0.01)。普通配方奶组在3月龄和6月龄时β乳球蛋白IgG阳性率明显高于低抗原配方奶组(P<0.01)。两组牛奶特异性IgE和卵蛋白IgG4的阳性率的差异无显著性(P>0.05)。两组新生儿的体重、身高和头围的差异也无显著性(P>0.05)。结论低抗原配方奶对于伴有过敏遗传因素的婴儿,能显著降低其过敏的发生率,而且具有与普通配方奶相当的营养学价值。Objective To appraise the preventive effect of hydrolyzed formula on infantile allergy. Methods Physical growth, serum specific IgE against milk protein and egg, specific IgG4 against β lactoglobulin and egg were carried out in ninety-five infants （65 fed with hydrolyzed formula as HA group and 32 fed with regular formula as control group） with high risks of allergies （bifamilial or unifamilial） during the first 6 months of life. Allergic symptoms were also investigated until 12 months of age. Results The incidences of eczema asthmatic bronchitis in the HA group were obviously lower than those of the control group at 3 months, 6 months and 12 months after birth. Serum specific IgG4 against β lactoglobulin was detected in 10 of 63 infants （15.8%） at 3 months after birth in HA group, 15 of 32 subjects （46. 8%） in the control group （x^2 =10.5, P〈0.01）. Moreover, a significant difference could be simultaneously noted in the positive rate of specific IgG4 against β lactoglobulin between the two groups at the age of 6 months （15.8% vs 52. 5%, x^2=21,35, P〈0.01）. But the difference of the positive rate of serum specific IgE against milk protein and specific IgG4 against egg at the age of 3 and 6 months were not significant between the two groups. The parameters of the physical development in HA infants reach the similar level as the controls during the first 6 months of life. Conclusions The hydrolyzed formula not only reduces the incidence of allergic symptoms in infants at risk for allergies, but also offers balanced nutrition as regular formula. We suggest that the infants with high risk of allergies should be fed with hydrolyzed formula. （Shanghai Med J, 2005, 28：640-642）

关 键 词：食物过敏 低抗原配方奶 婴儿 配方奶喂养 前瞻性研究 抗原 过敏 预防 哮喘性支气管炎 特异性IGE 

分 类 号：R174[医药卫生—妇幼卫生保健]