凋亡细胞被识别和吞噬机制  

Recognition and Engulfment Mechanism of Apoptotic Cells

作　　者：王强[1] 丁裕斌[1] 潘敏慧[1] 鲁成[1] 

机构地区：[1]西南农业大学蚕学与生物技术学院农业部蚕桑学重点实验室,重庆400716

出　　处：《细胞生物学杂志》2005年第4期383-386,共4页Chinese Journal of Cell Biology

基　　金：国家高技术研究发展计划(863计划)(No.2004AA2Z1020);国家自然科学基金(No.30471312)资助项目~~

摘　　要：凋亡细胞能被吞噬细胞吞噬,这对于正常组织的动态平衡和免疫反应是非常重要的。在凋亡细胞被吞噬(engulfment)的过程中,吞噬细胞表面存在大量的受体来识别凋亡细胞发出的信号,如:“吃我(eat-me)”信号、缺少存在于健康细胞上的“不吃我(don’t-eat-me)”信号以及由凋亡细胞分泌的可溶性“来吃我(come-get-me)”信号。至少有7种线虫(Caenorhabditiselegans)吞噬基因(它们在哺乳动物中存在同系物)组成了两条平行但部分重叠的吞噬信号通路,并且通过一个类似于巨胞饮(macropinocytosis)的“栓系-激活(tetherandtickle)”保守机制吞噬凋亡细胞,这个机制因吞噬细胞和凋亡细胞的种类以及细胞凋亡后的时间差异而不同。Apoptotic cells can be engulfed by phagocytes. This process is greatly crucial for normal tissue homeostasis and immune responses. During engulfment, a number of receptors on phagocytes are implicated in recognizing signals from apoptotic cells, such as “eat-me” signals, the absence of “don＇t-eat-me” signals normally found on healthy cells, as well as soluble “come-get-me” signals secreted by preys. At least seven engulfment genes in Caenorhabditis elegans （they have homologues in mammals） constitute two parallel but partially overlapped signaling pathways to induce the engulfment of apoptotic cells by a conserved “tether and tickle” mechanism akin to macropinocytosis. However, the mechanism probably varies with the apoptotic cells and phagocytes types, even with the age of corpses.

关 键 词：吞噬细胞 凋亡细胞 吞噬 信号途径 机制 识别 信号通路 免疫反应 细胞表面 细胞分泌 

分 类 号：Q255[生物学—细胞生物学] S852.4[农业科学—基础兽医学]