缺氧诱导因子在哺乳动物生殖的作用  

Roles of hypoxia-inducible factor in mammalian reproduction

作　　者：单春华[1] 赵越超[1] 杨增明[1] 

机构地区：[1]东北农业大学生命科学学院

出　　处：《生殖医学杂志》2005年第4期247-251,共5页Journal of Reproductive Medicine

基　　金：国家自然科学基金资助(30270163)

摘　　要：哺乳动物可启动许多基因调节体内的氧平衡,而缺氧诱导因子(hypoxia-inducible factor,HIF)是其中的核心因素。HIF广泛存在于动物体内,可调控许多基因的表达参与生理或病理过程。近年来随着基因敲除技术的应用,人们对HIF功能的认识不断深入。本文综述了HIF在哺乳动物的胚胎着床、胎盘形成、胚胎发生以及雄性生殖等过程中的作用。There are many genes involved in the regulation of oxygen homeostasis in mammals, and hypoxia-inducible factor （HIF） participates in this process as a core mediator. HIF expresses widely in many different kinds of animal tissues as a transcriptional regulator of many genes and so plays roles in some physical and/or pathological processes. The new insights have been provided as the development and application of gene-knockout technology. The functions of HIF during the processes of embryo implantation, placentation, embryogenesis and male reproduction in mammals will be reviewed in this article.

关 键 词：缺氧诱导因子 着床 胎盘 胚胎 生殖 

分 类 号：Q26[生物学—细胞生物学]