大剂量参附液治疗婴幼儿哮喘36例临床疗效观察  

Observation about the clinical effects of 36 cases of infant asthma with shenfu liquid in macro-dosage

作　　者：骆日英 

机构地区：[1]广东燕岭医院门诊部,广东广州510507

出　　处：《中国基层医药》2005年第8期967-968,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察参附液治疗婴幼儿哮喘的临床疗效,探讨婴幼儿哮喘新的治疗方法。方法对符合2003年修订的儿童支气管哮喘防治常规(试行)中婴幼儿诊断标准的101例哮喘患儿,随机分为大剂量参附液组(A组,3ml·kg-1·d-1静脉滴注),小剂量参附液组(B组,1ml·kg-1·d-1静脉滴注),地塞米松组(C组,0·15mg·kg-1·d-1,静脉滴注),疗程5d,观察用药后的疗效。结果A组哮喘缓解时间为(23·5±5·6)h,哮鸣音消失时间为(4·3±1·2)d,治疗前、后PaO2、PaCO2、pH值、哮喘复发次数均较B组为优(P<0·01),急性期的疗效与C组接近(P均>0·05)。结论大剂量参附液对婴幼儿哮喘效果显著,急性期有拮抗支气管痉挛作用,同时有预防哮喘发作的效果,无明显不良反应,有临床应用推广的价值。Objective To observe the clinical effects of shenfu liquid treating infant asthma and to explore new therapy means of infant asthma. Methods 101 cases who coincided with the infant criteria formulated by nation preventing child＇s asthma association in 2003 were divided into the macro-dosage shenfu liquid group（A group, 3ml·kg^-1·d^-1, ivgtt. ）. the micro-dosage shenfu liquid group（B group, 1ml·kg^-1·d^-1 ） and the dexamethasone group（C group,0.15mg·kg^-1·d^-1）. The course was 5 days. We investigated their effects after medication. Results The asthma remission time of A group was （23.5 ± 5.6） h. A group＇ s abolition time of wheezing sound was （4.3 ± 1.2）d. The changes of pre- and post-therapy＇s PaO2,PaCO2 and pH were better than B group＇s（P〈 0.01） and also the asthma relapse frequency. The effect of A group in acute period was as good as C group（P 〉 0.05）. Conclusions The effect of macro-dosage Shenfu liquid treating infant asthma is obvious. The macro-dosage shenfu liquid can restrict bronchial spasm in acute period and prevent asthma attack. It has no obvious side-effect .so it has the value of clinical extension.

关 键 词：哮喘 参附汤 儿童 临床疗效观察 婴幼儿哮喘 治疗方法 参附液 大剂量 支气管痉挛 静脉滴注 

分 类 号：R725.6[医药卫生—儿科]