3T MRI上鼠脑多体素^1H-MRS成像因素及其代谢物比值研究  

Affected Factors and Metabolic Ratio of Multi-voxel Proton MR Spectroscopy in Healthy rat Brain on 3T MR

作　　者：于同刚[1] 戴嘉中[1] 李克[1] 

机构地区：[1]复旦大学附属华山医院放射科,200040

出　　处：《中国医学计算机成像杂志》2005年第4期276-278,共3页Chinese Computed Medical Imaging

摘　　要：目的:探讨影响鼠脑多体素1H-MRS的成像因素及在3T MRI上正常鼠脑代谢物值.材料和方法:40只正常雄性SD大鼠,体重200～250g.利用3T MRI扫描机、大鼠专用线圈对SD大鼠尾状核行二维多体素1H-MRS检查,采用点分辨波谱(PRESS)序列,TR/TE=1000ms/35ms,FOV 60mm,层厚4mm,NEX 1;利用波谱后处理软件FuncTool重建SD大鼠正常尾状核Cho/Cr、Cho/NAA、NAA/Cr的比值.结果:40只行多体素1H-MRS检查的正常SD大鼠,其尾状核Cho/Cr的平均值为0.97±0.20、Cho/NAA为0.79±0.33、NAA/Cr为1.34±0.34.在多体素1H-MRS检查中,关键要选择合适的体素位置,并对匀场进行优化,同时要恰如其分的放置饱和带.结论:在3T MRI上进行鼠脑多体素1H-MRS切实可行;通过测定正常鼠脑的代谢物比值,为以后的科研工作提供有价值的参考值.Purpose： To explore the affected factors of multi - voxel proton MR spectroscopy in rat brain, and the metabolic ratio measured in healthy rat brain on 3T MR. Materials and Methods： 40 healthy male SD rats, weighted 200 - 250g. multi - voxel proton MR spectroscopy in caudate nucleus on 3T MR were performed with PRESS sequence and special coil, TR/ TE 1000ms/ 35ms, FOV 60mm, slice thickness 4ram, NEX 1. The metabolic ratios were reconstructed using FuncTool software. Results： The mean metabolic ratios in caudate nucleus of healthy rat brain were as follow： Cho/ Cr 0.97±0.20; Cho/ NAA 0.79±0.33; NAA/ Cr 1.34±0.34. optimize the voxel location, shiming and saturation band is very important for multi - voxel proton MR spectroscopy. Conclusion： It is feasible to do multi - voxel proton MR spectroscopy in rat brain with 3T MR and the metabolic ratio measured in healthy rat brain can be used for reference in future studies.

关 键 词：磁共振成像 磁共振波谱 大鼠 ^1H-MRS MRI扫描机 脑代谢物 成像因素 多体素 鼠脑 比值 

分 类 号：R445.2[医药卫生—影像医学与核医学]