干烧黄芪鱼对衰老小鼠SOD、GSH-Px、NO和NOS的影响  

Effect of Carp Baked with Radix Astragali seu Hedysari on SOD,GSH-Px,NO and NOS of Aging Mice

作　　者：施洪飞 项平[2] 申毓军 王素兰 

机构地区：[1]扬州大学营养科学系,江苏扬州225001 [2]南京中医药大学,江苏南京210029 [3]扬州大学体育运动和营养保健专业,江苏扬州225001

出　　处：《南京中医药大学学报》2005年第5期299-301,共3页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省科技厅社会发展项目(BS99080)

摘　　要：目的研究药膳干烧黄芪鱼对造模衰老小鼠SOD、GSH-Px、NO和NOS的影响,并探讨药膳保健的可能性。方法用干烧黄芪鱼掺和到饲料中饲养实验性衰老小鼠40 d,测定小鼠脑、肾超氧化物歧化酶(SOD)活力、小鼠肝谷胱甘肽过氧化物酶(GSH-Px)活力,小鼠睾丸、脑中一氧化氮(NO)含量和睾丸、血清中一氧化氮合成酶(NOS)活力。结果干烧黄芪鱼低、中剂量组肾SOD活力与实验对照组比较差异有显著性(P<0.05),高剂量组与实验对照组比较有极显著性差异(P<0.01)。干烧黄芪鱼高剂量组肝GSH-Px活力与实验对照组比较有十分显著性差异(P<0.01)。干烧黄芪鱼低、中剂量组睾丸NO含量与实验对照组比较有显著性差异(P<0.05)。干烧黄芪鱼低剂量组睾丸NOS活力与实验对照组比较差异有显著性(P<0.05)。结论药膳干烧黄芪鱼具有一定的抗氧化作用,并对雄性衰老小鼠生殖系统NO含量及NOS活力有一定影响;以药膳的形式能够达到保健作用。OBJECTIVE To investigate into the effect of carp baked with Radix Astragali seu Hedysari on SOD, GSH - Px, NO and NOS of aging mice and explore into the possibility of health care with medicinal diet. METHOD Aging mice were fed with feedstuff mixed with carp baked with Radix Astragali seu Hedysari for 40 days, followed by determination of various indexes. RESULT In the groups with low and median dosage of carp baked with Radix Astragali seu Hedysafi and the groups with median dosage of Radix Astragah seu Hedysari, SOD activity was markedly different from the experimental control group （ P 〈 0.05 ） ; this difference also existed between the high dosage groups and the experimental control group （ P 〈 0.05）. In the groups of carp baked with Radix Astragali seu Hedysafi, the activity of liver GSH - Px was marked different from the experimental control group （ P 〈 0.01 ）. In the groups with low and median dosage of carp baked with Radix Astragali seu Hedysari, test is NO was markedly different from the experimental control group （P〈0.05）. In the groups with low dosage of carp baked with Radix Astragali seu Hedysafi, NOS activity was markedly different from the experimental control group （P 〈 0.05）. CONCLUSION The medicinal diet carp baked with Radix Astragali seu Hedysafi has certain anti - oxidation effect and can affect NO content and NOS activity of aging mice. Therefore, medicinal diet can be used for health care purposes.

关 键 词：黄芪 鲤鱼 老年鼠 超氧化物歧化酶 谷甘肽过氧化物酶 一氧化氮合成酶 

分 类 号：R285.5[医药卫生—中药学]