黄芪总提物体内外抗血栓作用的实验研究  

Effects of total Astragalus extract on anti-thrombus

作　　者：朱虹[1] 吴强[2] 徐明[1] 吴樱樱[1] 胡秀萍[1] 邹宇宏[3] 杨雁[1] 

机构地区：[1]安徽医科大学药理教研室 [2]安徽医科大学病理学教研室 [3]安徽医科大学药学院

出　　处：《中国临床药理学与治疗学》2005年第8期917-920,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:研究黄芪总提物的体内外抗血栓作用。方法:黄芪总提物按15、50、150mg·kg-1灌胃给药,采用尾静脉注射胶原蛋白-肾上腺素混悬液诱发小鼠体内血栓形成,观察注射后5min内小鼠的死亡数和15min内偏瘫的未恢复数,计算阳性率与保护率,并取肺组织做病理学检查。采用大鼠腹主动脉插管放血,体外试管法测定黄芪总提物对大鼠血凝块的溶解作用。结果:黄芪总提物(15、50、150mg·kg-1)对胶原蛋白-肾上腺素诱发的小鼠体内血栓形成有明显的保护作用(P<0.01);黄芪总提物(40、80、160、320mg·L-1)对体外形成大鼠血凝块有明显的溶解作用(P<0.05)。结论:黄芪总提物有抑制体内血栓形成和体外直接溶解血凝块作用,提示黄芪总提物具有一定的活血化淤作用。AIM： To studv the effects of the total Astragalus extract on anti-thrombus. METHODS： The thrombus formation in mice was induced by i. v injection of a mixture of collagen and epinephrine. The mice which died within 5 min and remained paralyzed for more than 15 min were observed, and the protect rate were calculated. Furthermore, the lung tissues wese made by histological examination. The blood of rat was gained from abdominal aorta, and the effects of the total Astragalus extract which resolved rat blood clot were tested by tube in vitro. RESULTS： The total Astragalus extract （50 and 150mg·kg^-1 ）reduced the death rate resulted from thrombosis induced by mixture of collagen and epinephrine （i. v） in mice. The total Astragalus extract（40, 80, 160, and 320 mg· L^-1 ） resolved blood clot Total Astragalus extract has thrombus formation in vivo in vitro. CONCLUSION： obvious effects of inhibiting and resolving blood clot in vitro. It suggests the total Astragalus extract has the ef- fects of activating blood to resolve stagnation.

关 键 词：黄芪总提物 抗血栓 活血化淤 胶原 肾上腺素 

分 类 号：R975[医药卫生—药品]