N-乙基-2,3-二氧代哌嗪的合成  

Synthesis of N-ethyl-2,3-dioxopiperazine

作　　者：许建帼[1] 谢建伟[1] 吴敏 邵丽莉 

机构地区：[1]浙江工业大学浙西分校化工系,浙江衢州324006 [2]浙江巨化技术中心,浙江衢州324004

出　　处：《精细化工中间体》2005年第4期18-19,共2页Fine Chemical Intermediates

摘　　要：以N-乙基乙二胺和草酸二乙酯为原料,在氯化胺催化作用下脱醇缩合得N-乙基-2,3-二氧代哌嗪。实验研究了反应物摩尔配比、反应时间、反应温度、催化剂用量等对N-乙基-2,3-二氧代哌嗪收率影响,得出了优惠工艺条件:催化剂用量为N-乙基乙二胺质量的1.5%,原料草酸二乙醇与N-乙基乙二胺摩尔比为1.02∶1,反应温度为20℃,乙酸用量200mL。总收率达到85%。N-ethyl-2,3-dioxopiperazine was synthesized from N-ethylethylenediamine and diethyl ethanedioate by condensation reaction with catalyst ammonia chloride .The effects of mole ratios, reaction time, temperature and the amount of catalyst on the yields of N-ethyl-2,3-dioxopiperazine were investigated ,The optimal condition was as follows：w （cat）=1.5% （N-alkylethylenediamin）,n （diethylethanedioate）：n （N- alkylethylenediamine）=1.02： 1, reaction temperature 20℃, ethanol zooml,The yield of N-ethyl-2,3-dioxopipevazine was more than 85%.

关 键 词：N-乙基乙二胺 N-乙基-2 3-二氧代哌嗪 哌拉西林 

分 类 号：TQ252[化学工程—有机化工]