氟咯草酮的合成研究  

Synthesis of Herbicide Fluorochloridone

作　　者：杨剑波[1] 庞怀林[1] 黄超群[1] 

机构地区：[1]湖南化工研究院,湖南长沙410007

出　　处：《精细化工中间体》2005年第4期24-27,共4页Fine Chemical Intermediates

摘　　要：以N-烯丙基-间-三氟甲基二氯乙酰苯胺为原料,在催化剂作用下重排制得氟咯草酮,对反应条件进行了研究,得出了合成氟咯草酮及相关中间体的优惠条件为:铜催化剂用量的7.5g/mol,反应温度110℃,反应时间3h。中间体N-烯丙基-间-三氟甲基苯胺的反应收率超过90%,N-烯丙基-间-三氟甲基-二氯乙酰替苯胺的收率超过95%,氟咯草酮的收率超过85%,产品纯度超过90%。The Herbicide Fluorochloridone [3-chloro-4-（chlorometheyl）-l-[3-（trifluoromethyl） phenyl]-2- pyrrolidinone] was prepared from 2,2-dichloro-N-2-propenyl-N- [3-（trifluoromethyl） phenyl]-acetamide in the presence of catalyst, and the optimal reaction conditions of Fluorochloridone and its intermediates were obtained in the laboratory.The optimum conditions of Fluorochloridone was as follow,reaction temperature 110℃ ,reaction time 3 h ,the amount of Cu catalyst 7.5 g/mol.The yield of the intermediate N-（2-propenyl）-3-（trifluoromethyl） benzenamine and 2,2-dichloro-N-2-propenyl-N-[3-（trifluoromethyl） phenyl]-acetamide exceeded 90% and 95%, respectively. The yield and purity of fluorochloridone reached more than 85% and 90%, respectively, under the optimal conditions.

关 键 词：除草剂 氟咯草酮 N-烯丙基-3-三氟甲基-二氯乙酰替苯胺 二氯乙酰氯 N-烯丙基-间三氟甲基苯胺 

分 类 号：TQ457[化学工程—农药化工]