金银花抗豚鼠巨细胞病毒的体外实验研究  

Experimental study of honeysuckle flower against guinea pig cytomegalovirus in vitro

作　　者：王昕荣[1] 陈素华[1] 乔福元[1] 熊锦文[1] 刘海智[1] 王楠[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,430030

出　　处：《中国妇幼保健》2005年第17期2241-2243,共3页Maternal and Child Health Care of China

基　　金：国家自然科学基金资助项目(基金编号:39970769)

摘　　要：目的研究中药金银花体外抗豚鼠巨细胞病毒的效果。方法用细胞病变法和MTT法检测金叶败毒及金银花的最大无毒浓度和最小有效浓度,计算其治疗指数。结果金银花和金叶败毒的最大无毒浓度均为3×10-3mg/ml,金银花和金叶败毒的最小有效浓度分别为3×10-4mg/ml和3×10-5mg/ml,治疗指数分别为100和10。结论金银花具有体外抗豚鼠巨细胞病毒的作用,但抗病毒作用低于金叶败毒。Objective： To study the effect of honeysuckle flower against guinea pig cytomegalovirus （GPCMV） in vitro. Methods： The TDO and MTC of jinyebaidu （JYBD） and honeysuckle flower were determined by cytopathic effect and MTT methods to calculate their therapeutic index （TI） . Results ： TD0 of honeysuckle and JYBD were 3 × 10^-3 mg/ml ; MTC of honeysuckle and JYBD were 3 × 10^-4 mg/ml and 3×10 ^-5 mg/ml, respectively, TI were 100 and 10 respectively. Conclusion： Honeysuckle has the effect of anti -GPCMV in vitro, but its anti -virus function was lower than that of JYBD.

关 键 词：巨细胞病毒 豚鼠 金银花 

分 类 号：R28[医药卫生—中药学]