2型糖尿病下肢血管病变发生率及危险因素分析  

The prevalence of vascular lesions in the lower extremities and the related risk factors in patients with type 2 diabetes

作　　者：刘颖慧[1,2] 李红[1] 范慧[1] 

机构地区：[1]浙江大学医学院附属第一医院内分泌科,杭州310003 [2]杭州市红十字会医院内分泌科

出　　处：《中国实用内科杂志》2005年第9期825-826,共2页Chinese Journal of Practical Internal Medicine

摘　　要：目的了解2型糖尿病患者下肢血管病变(PVD)发生率,分析PVD的相关危险因素.方法对2000～2003年在浙江大学医学院附属第一医院内分泌科住院治疗297例2型糖尿病患者进行回顾性分析(单因素及Logistic回归分析).结果 64.98%(193/297)患者多普勒超声检查提示有下肢血管病变.年龄、病程、24 h尿白蛋白(UAE)、血尿酸(UA)、血肌酐(Cr)、收缩压增高比例、周围神经病变(DPN)比例、冠心病(CHD)比例在有下肢血管病变者中均显著增高(P<0.01).Logistic回归分析结果表明,年龄、总胆固醇(Tch)、DPN是PVD的独立危险因素(OR=1.087,1.353,2.201).结论 2型糖尿病患者下肢血管病变发生率高,与年龄、血脂、血压、血糖以及糖尿病其它慢性并发症多种因素相关.Objective To investigate the prevalence of vascular disease in the lower extremities and its related risk factors in patients with type 2 diabetes. Methods 297 in-patients with type 2 diabetes in the First Affiliated Hospital of Zbejiang University during the years of 2000- 2003 were screened for peripheral vascular disease （PVD） by Doppler Ultrasonic examination, and the related risk factors for PVD were analysed. Results 193 patients （64.98 % ） showed different degrees of vascular lesions in the lower limbs in 297 diabetic patients. Age, durations of diabetes, 24 hours urinary albumin excretion, serum uric acid, creatinine levels, the existence of higher systolic blood pressure, diabetic peripheral neuropathy and coronary heart disease were significantly higher in the diabetic patients with PVD compared with those without PVD. Age, total serum cholesterol level, and diabetic peripheral neuropathy were independent risk factors for the vascular disease in the lower extremities of type 2 diabetic patients. Conclusion There are high preva- lence of vascular lesions in lower limbs in type 2 diabetic patients, and it is associated with age, hyperlipemia raised blood pressure, hyperglycaemia and other chronic complications of diabetes.

关 键 词：2型糖尿病 下肢血管病变 多普勒超声检查 

分 类 号：R5[医药卫生—内科学]