EAE大鼠民用航空药前后临床评分的比较  

Compare the EAE Rat Clinicl Symptoms Being Used Medicines After Illness

作　　者：刘华[1] 刘颖[1] 辛晋敏[1] 马太花[1] 梁丽云[1] 马存根[1,2] 

机构地区：[1]山西大同大学脑科研究所,山西大同037008 [2]山西医科大学第一临床医学院神经科,山西太原030001

出　　处：《山西医学教育》2005年第1期47-49,共3页

摘　　要：目的：探讨在EAE大鼠发病过程中，雷公藤内酯醇及雷公藤内脂醇与地塞米松的联合使用对发病进程、临床评分的影响。方法：将Wistar种健康、雌性大鼠左后肢足垫皮下注射CFA-GPSCH抗原乳剂0.4ml/只，右足背皮下或皮内注射PT0.05ml/只（含5.0×10^9个菌体）。设免疫当日为零天，每天称重，采用双盲法两人进行临床症状评分。结果：免疫后15d，取临床评分相同者的归为一个级别，共获得3个级别的动物，每个级别的动物分成三组分别给予生理盐水、雷公藤内脂醇、雷公藤内脂醇和地塞米松的共同使用。结论，雷公藤组和联合组的发病进程缩短，临床评分明显下降。objective： to observe the symotom and process of clinical in EAE wistar rat used the triptolide and triptolide co - treatment with dexamethasone. Methods healthy, female wintar rats are injected the 0.4ml CFA-GPSCH/rat and 0.05mlPT/rat. The injection day is zero, everyday the rat is weighted, the doube - blind method is used. Results Post inoculation 15, the same symptoms is the same level, there are three, the same level is divided three group given by normal saline, triptolide and the mixture of triptolide and dexamethasone. Condutions the symptom and process of triptolide group and the co-treatment group are cut dowm.

关 键 词：EAE 雷公藤内脂醇 临床评分 雌性大鼠 民用航空 雷公藤内酯醇 WISTAR 发病进程 联合使用 地塞米松 

分 类 号：R656.8[医药卫生—外科学] R681[医药卫生—临床医学]