罗汉果中一新葫芦烷型三萜皂苷——光果木鳖皂苷Ⅰ  

Grosmomoside Ⅰ, a new cucurbitane triterpenoid glycoside from fruits of Momordica grosvenori

作　　者：杨秀伟[1] 张建业[1] 钱忠明[2] 

机构地区：[1]北京大学天然药物及仿生药物国家重点实验室北京大学医药卫生分析中心,北京100083 [2]香港理工大学应用生物及化学科技学系

出　　处：《中草药》2005年第9期1285-1290,共6页Chinese Traditional and Herbal Drugs

摘　　要：目的研究罗汉果中的化学成分。方法用各种色谱法分离和精制纯品化合物,通过各种谱学方法鉴定其结构。结果从罗汉果乙醇提取物中得到4个葫芦烷型三萜皂苷,分别为:罗汉果皂苷E(mogroside ⅡE,Ⅰ)、罗汉果皂苷(mogroside Ⅲ,Ⅱ)、光果木鳖皂苷(grosmomoside Ⅰ, Ⅲ)和罗汉果皂苷(mogroside Ⅴ,Ⅳ)。结论光果木鳖皂苷为一新化合物,鉴定其结构为罗汉果醇-3-O-β-D-吡喃葡萄糖苷-24-O-{[β-D-吡喃葡萄糖基(2-1)]- [β-D-吡喃葡萄糖基(6-1)]-β-D-吡喃半乳糖苷{mogrol-3-O-β-D-glucopyranoside-24-O-[β-D-glucopyranosyl(2-1)]- [β-D-glucopyranosyl(6-1)]-β-D-galactopyranoside},其他3个化合物为已知化合物。Objective To carry out a systematic study on the chemical constituents in the fruits of Momordica grosvenori. Methods To isolate pure compounds by using repeated column chromatography, while the structure of a new compound was determined by detailed spectral analysis. Results Four cucurbitane triterpenoid glycosides, mogroside Ⅱ E （ Ⅰ ）, mogroside Ⅱ （ Ⅱ ）, grosmomoside Ⅰ （ Ⅲ ）, and mogroside Ⅴ （ Ⅳ ） were isolated from the 50% ethanolic extract of the fruits of M. grosvenori. Conclusion Grosmomoside Ⅰ is a new compound identified as mogrol-3-O-β-D-glucopyranoside-24-O-{β-D-glucopyranosyl （2-1） [β-D-glucopyranosyl （6-1）]-β-D-galactopyranoside} and the other three compounds are known compounds.

关 键 词：罗汉果 三萜皂苷 光果木鳖皂苷1 

分 类 号：R284.1[医药卫生—中药学]