蒙古黄芪中黄酮类成分的研究  

Flavonoid constituents of Astragalus membranaceus var. mongholicus

作　　者：马晓丰[1] 田晓明[1] 陈英杰[2] 屠鹏飞[1] 

机构地区：[1]北京大学医学部药学院,北京100083 [2]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《中草药》2005年第9期1293-1296,共4页Chinese Traditional and Herbal Drugs

基　　金：国家经贸委2000年度中药材生产扶植资金项目(国经贸医药[2000]56号)

摘　　要：目的研究蒙古黄芪的化学成分,为该中药的开发利用和质量评价提供依据。方法利用多种色谱方法分离纯化,通过理化常数测定和波谱分析鉴定其化学结构。结果从蒙古黄芪中分离鉴定了9个黄酮类化合物,分别为芒柄花素(formononetin,Ⅰ)、(3R)-8,2′-二羟基-7,4′-二甲氧基异黄烷[(3R)-8,2′-dihydroxy-7,4′-dimethoxy-isoflavane,Ⅱ]、毛蕊异黄酮(calycosin,Ⅲ)、(6aR,11aR)9,10-二甲氧基紫檀烷-3-O-β-D-葡萄糖苷[(6aR,11aR)9,10-dimethoxypterocarpan-3-O-β-D-glucoside,Ⅳ]、7,2′-二羟基-3′,4′-二甲氧基异黄烷-7-O-β-D-葡萄糖苷(7,2′-di-hydroxy-3′,4′-dimethoxy-isoflavane-7-O-β-D-glucoside,)、芒柄花素-7-O-β-D-葡萄糖苷(formononetin-7-O-β-D-glucoside,Ⅴ)、毛蕊异黄酮-7-O-β-D-葡萄糖苷(calycosin-7-O-β-D-glucoside,Ⅵ)、红车轴草异黄酮-7-O-β-D-葡萄糖苷(pratensein-7-O-β-D-glucoside,Ⅶ)和染料木苷(genistin,(Ⅸ))。结论化合物为首次从黄芪属植物中分得,化合物为首次从该种植物中获得,化合物～具有促进细胞增殖的活性。-Objective To study the chemical constituents of Astragalus membranaceus var. mongholicus. Methods The constituents were isolated and purified by several chromatographic techniques and identified by chemicophysical properties and spectral analyses. Results Nine flavonoid compounds had been obtained from A. membranaceus var. mongholicus. They were determined as formononetin （ Ⅰ ）, （ 3R ）-8, 2′-dihydroxy-7, 4′-dimethoxy-isoflavane （ Ⅱ ）, calycosin （ Ⅲ ）, （ 6aR, llaR ） 9, 10- dimethoxypterocarpan-3-O-β-D-glucoside （ Ⅳ ）, 7, 2′-dihydroxy-3′, 4′-dimethoxy-isoflavane-7-O-β-D-glu- coside （Ⅴ）, formononetin-7-O-β-D-glucoside （VI）, calycosin-7-O-β-D-glucoside （Ⅵ）, pratensein-7-O-β-D-glucoside （Ⅶ）, and genistin （ Ⅸ ）, respectively. Conclusion Compound Ⅶ is obtained from the plants of Astragalus Linn. for the first time and compound Ⅱ is obtained from this plant for the first time. Compounds Ⅰ-Ⅶ show cell multiplication activity.

关 键 词：黄芪属 蒙古黄芪 黄酮类 

分 类 号：R284.1[医药卫生—中药学]