超滤膜纯化夏天无总碱的研究  

Purification of Rhizoma Corydalis Decumbentis total alkaloids by ultrafiltration membrane technology

作　　者：朱才庆[1] 余华[1] 范其坤[1] 熊胜泉[1] 徐丽英[1] 魏东芝[2] 

机构地区：[1]江西省药物研究所天然药物研究室,江西南昌330029 [2]华东理工大学生物反应器工程国家重点实验室,上海200237

出　　处：《中草药》2005年第9期1319-1322,共4页Chinese Traditional and Herbal Drugs

基　　金：江西省重大科技攻关项目(赣科发计字[2002]64号)

摘　　要：目的探讨应用超滤膜分离技术纯化夏天无总碱工艺。方法采用不同截留分子的膜组件、操作参数进行正交设计,以与原阿片碱相关的各种指标考察不同膜组件及操作参数对膜分离效果的影响。结果截留相对分子质量为6×103～1.0×104的PS膜具有较好的膜分离效果,选择压力0.08MPa、料液温度40℃、进料体积流量2.8L/min的操作参数工作效率更高。结论利用膜分离工艺制备的夏天无注射液澄清、色泽好,显示出更强的药效作用。Objective 1 o explore the possloulty for to purify Rhizoma Corydalis Decumbentis total alkaloids application oi ultrallltration membrane technology （RCDTA）. Methods Based on the index related to protopine, to investigate the effect of different aperture membrane and orthogonal test of separation parameters on membrane saparation efficiency of Xiatianwu Injection. Results The PS membrane with 6 × 10^3-1.0×10^4 interception molecular weight had better separation efficiency and the preferred operation parameters were 0.08 MPa of pressure, 40C of liquid temperature, and 2.8 L/min of liquid speed. Conclusion Xiatianwu Injection prepared by ultrafiltration membrane technology is clear with good colour and better drug function.

关 键 词：夏天无总碱 原阿片碱 膜分离 药效作用 

分 类 号：R284.2[医药卫生—中药学]