吸入糖皮质激素联合穴贴对哮喘患儿免疫功能的影响  

Effect of corticosteroid inhalation and acupoint sticking on immune function in asthmatic children

作　　者：林玉娟[1] 顾秋枫[1] 鞠琰莉[1] 彭华[1] 丁小容[1] 

机构地区：[1]北京大学深圳医院儿科,广东深圳518036

出　　处：《广东医学院学报》2005年第5期510-512,共3页Journal of Guangdong Medical College

摘　　要：目的:探讨吸入糖皮质激素和联合中药穴贴对小儿哮喘免疫功能的影响。方法:30例哮喘患儿随机分为布地奈德干粉(普米克都保)吸入15例(简称普米克组)和中药穴贴(天灸)联合普米克都保吸入组15例(简称联合治疗组),健康对照组15例。分别在治疗前、治疗后1、3个月测定PEFR值,并于治疗前、治疗后3个月测定血清IL-12I、L-4I、L-8水平(采用ELISA法)。以日记的形式记录哮喘日间、夜间症状及使用β2受体激动剂万托林的次数,判断临床疗效。结果:治疗1个月后,两组PEFR值均有明显改善(P<0.05或<0.01),治疗3个月后全部患者的PEFR值均上升至正常预测值的90%以上。联合治疗组的日间及夜间症状消失时间较普米克组快(P<0.01),且联合治疗组使用万托林的剂量比普米克组明显减少(P<0.01)。两组患者治疗前IL-4及IL-8水平均明显高于正常对照组,IL-12水平则明显低于正常对照组(P<0.01);治疗3个月后复查血清IL-4I、L-8水平明显下降,IL-12明显上升,均恢复至正常对照组水平。结论:两组药物治疗方法均能影响哮喘患儿的血清细胞因子水平;联合治疗组临床症状改善较普米克组迅速。Objective： To study the effect of corticosteroid inhalation and acupoint sticking on immune function in asthmatic children. Methods： Thirty children with asthma were randomly divided into two even groups： pulmlcort group received pulmicort inhaler, and combination group accepted pulmicort inhaler and acupoint sticking. The peak expiratory flow rate （PEFR） and serum IL-4, IL-8 and IL-12 levels were determined before and 1. 3 months after treatment. Results： There was an obvious improvement of PEFR in 2 groups after treatment （P〈0.05 or 0.01）. especially in 3 months. The symptom disappearance was quicker, and ventolin dose was less in combination group compared with pulmicort grounp （P〈0. 01）. Serum IL-4, IL-8 and IL-12 levels returned to normal 3 months after treatment in 2 groups. Conclusion： Both of treatment schedules can affect serum cytokine contents in asthmatic children. Combined therapy can achieve rapid alleviation of clinical symptoms.

关 键 词：儿童 哮喘 普米克 穴贴 细胞因子 

分 类 号：R725.6[医药卫生—儿科]